Online ISSN: 2515-8260

Keywords : hemodynamic changes

Intravenous paracetamol versus dexmedetomidine in patients undergoing laparoscopic cholecystectomy: hemodynamic changes

Dr. Santosh Kumar, Dr. Deepak Vijay Kumar Kadlimatti, Dr. Salim Iqbal M, Dr. Renita Lincia, Dr. Harsoor SS

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 2, Pages 1436-1444

In laparoscopic surgeries, marked hemodynamic changes occur due to the effect of absorption, positioning of the patient, anesthetic agents and pneumoperitoneum. When the intra-abdominal pressure is < 10mmHg, hemodynamic alteration is not significant. Significant alteration in hemodynamics occurs, when the intra-abdominal pressure is > 10 mmHg after insufflation. When the intra-abdominal pressure is >10mmhg, it will cause inferior vena cava compression and pooling of blood in the lower extremities, which decreases the venous return to the heart thereby reducing the cardiac output. On receiving patient in operating room, the patient monitoring included electrocardiogram (ECG), noninvasive blood pressure (NIBP), heart rate (HR), oxygen saturation (SPO2). The baseline HR, NIBP, SpO2 scores were recorded. The hemodynamic parameters taken into consideration were the heart rate, systolic blood pressure, diastolic blood pressure, mean arterial blood pressure. Mean values of these parameters were analyzed from the baseline, every minute for the first 10 min thereafter for every 5 min till the end of surgery. The heart rate was significantly lower in dexmedetomidine group during the initial 10 min during infusion, lowest mean of 79.53±13.08, none of the patients from either group had bradycardia requiring atropine. Mean value of HR was higher in paracetamol group compared to dexmedetomidine group till 1 h postoperatively. Using preanesthetic dexmedetomidine 1μg/kg infusion followed by 0.5 μg/kg/h showed there was no difference in MAP between the groups, but heart rate of dexmedetomidine group was lower compared to the control group.

A Comparison of Ketamine-Propofol Versus Propofol as Induction Agents on Hemodynamic Parameters in Patients Undergoing Elective Surgical Procedures Under General Anesthesia

Prathap Sidda, Jhansi Gurram

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 5016-5028

Background:Propofol produces quick induction and recovery, depresses airway
reflexes, and is used for sedation and anaesthesia; nevertheless, it is associated with
dose-dependent hypotension and respiratory depression.It can produce coughing,
hiccups, laryngospasm, and movements when used as a sole agent to provide LMA.In
addition to its amnesic and analgesic effects, ketamine raises heart rate and blood
pressure through stimulating the sympathetic nervous system.It was shown that a
combination of ketamine and propofol decreased patients' use of propofol and opioids
and improved their hemodynamic and respiratory stability. Objectives:1. Determine
whether the ketamine-Propofol combination has more favourable hemodynamics than
the gold standard prototypic induction drug (Propofol) in a cohort of healthy patients.2.
To compare the additional post-operative analgesia requirements between the two
Materials and Methods: Group KP, the Ketamine-Propofol Group, provided 0.75mg/kg
of ketamine and 1.5mg/kg of Propofol to 60 patients with ASA status I who were
randomly divided into two groups. Group P – Propofol Group received 2 mg/kg
Propofol for induction. The airway is secured with LMA, and patients in both groups
were maintained with O2, N2O, and Sevoflurane. For the next 15 minutes, every three
minutes, the baseline hemodynamics, heart rate, NIBP, Spo2, and respiratory rate were
recorded. Pain scores were measured for each subject post-operatively. Additional
analgesia was supplied to all patients with a VAS > 3 who reported pain.
Results: In Group KP, the systolic, diastolic, mean arterial blood pressure, and heart
rate changes following LMA implantation were considerably greater than in Group P.
Group KP had longer recovery durations, lower VAS scores immediately following
surgery, and less analgesic needs. In neither group was there an occurrence of apnea,
hypoventilation, or emerging responses.
Conclusion: Ketofol is a mixture of ketamine and Propofol that has multiple
advantages.Hemodynamic stability, absence of respiratory depression, rapid recovery,
and potent postoperative analgesia. We thus advocate intravenous ketofol as an
induction drug, particularly for patients undergoing short surgical operations.

A Study to Observe the Hemodynamic Changes Following Insertion of I-gel and to Access Incidence of Any Postoperative Side Effects

Vineet Mishra, Akhilesh Mishra, Abha Singh, Vrushali Moharil

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 5803-5811

Introduction: Supraglottic airway devices (SADs) are used to keep the upper airway
open to provide unobstructed ventilation. I-gel is a second generation extraglottic
airway device. SADs now provide successful rescue ventilation in > 90% of patients in
whom mask ventilation or tracheal intubation is found to be impossible.The present
study was carried to observe the hemodynamic changes following insertion of I-gel and
to evaluate any incidence of post – operative sore throat or any other side effects.
Material and Methods: A prospective randomized controlled study was conducted on 40
patients scheduled for elective surgical procedures and requiring controlled ventilation.
Patients were induced with thiopentone 4-6 mg/kg. Size 3 I-gel was used in patients
weighing 30-60 kg and size 4 I-gel was used in patients weighing 60-90 kg. Correct I-gel
insertion was assessed clinically by subjective assessment of appropriate length of
airway tube outside the mouth, gastric insufflation and adequacy of manual ventilation
which was assessed by proper chest expansion and presence of CO2 waveform.
Results: Slight rise in MAP of 97.58±9.29 mmHg from BL value of 93.13±9.03 was
observed (p=0.836). The mean %age rise was 4.66±2.83 after insertion of the I-gel in
comparison with the base line value. It was found to be statistically insignificant.
Oxygen saturation was maintained between 99-100% for all the patients till the end of
the surgery. There was not any significant change in the ETCO2 after I-gel insertion. As
revealed from the data there was very less incidence of post-operative complications.
Two patients complained of sore throat at 6 hours and 24 hours post-operatively.


Dr.Ramlal Porika, Dr. Joshua Dhavanam Y ,Dr.P.AnandVijaya Bhasker, Dr.KommuriSudha

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 5962-5970

Aim: To compare the hemodynamic response to anaesthetic induction with thiopentone sodium or
etomidate in adult treated hypertensive patients posted for elective surgeries.
Materials and methods:A prospective randomised blind clinical study conducted in 60 adult treated
hypertensive patients(29-61 years) of ASA II posted for elective surgeries under general anaesthesia.
Patients were randomly allocated to two groups of 30 each. Group T-Thiopentone sodium 5mg/kg
body weight Group E-Etomidate 0.3mg/kg body weight. Pulse,systolic blood pressure, diastolic
blood pressure and mean arterial pressure were noted down every minute for five minutes post
Results: Both groups were comparable statistically for age, gender and weight.There was no
statistically significant variation in the extent of over all change in heart rate, systolic, diastolic and
mean arterial pressures between the two group of patients (p >0.05).All the studied hemodynamic
variations with respect to HR,SBP,DBPand MAP in the two groups were self corrective and did not
require any treatment. Patients in both groups did not have any side effects perioperatively and for 24
hours post operatively except for vomiting in one patient in group E.
Conclusion: Both thiopentone (5mg/kg) and etomidate (0.3mg/kg) have similar hemodynamic effects
when used for induction of anaesthesia in adult treated hypertensive patients and can be safely used in
them. However thiopentone comparatively has better cost effectiveness and ease of availability.

Intrathecal 0.5% hyperbaric bupivacaine with varying doses (30 μg Vs 60 μg Vs 90 μg) of buprenorphine in lower abdominal and lower limb surgeries; hemodynamic changes

Dr. U Sankara Rao, Dr. Richie Sanam, Dr. Moda Sree Rekha

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 2, Pages 2141-2146

Bupivacaine hydrochloride is 2-piperidenecarboxamide-1-butyl-N-(2, 6 dimethyl phenyl) monochloride, a monohydrate is a white crystalline powder that is freely soluble in 95% ethanol, soluble in water, and slightly soluble in chloroform or acetone. Local anesthetics mainly work on the cell membrane of the axon. The considerable transient rise in sodium ion permeability that's also required for impulse transmission is inhibited. Depolarization in response to the stimulus is thereby blocked, and the resting membrane potential is preserved. A pre-anesthetic check-up was done one day before the surgery. Patients were evaluated for any systemic diseases and laboratory investigations were recorded. The procedure of SAB was explained to the patients and written consent was obtained. The preparation of patients included a period of overnight fasting. Hemodynamics during the operative period was similar in the 30 mcg group and 60 mcg, but for the 90 mcg group incidence of hypotension and respiratory depression was observed for a few cases.

Oral gabapentin (600mg) versus oral pregabalin (75mg) for orthopedic surgery under spinal anesthesia: Hemodynamic changes

Dr. Rahul Bankapur, Dr. Preeti Lamba, Dr. Rahul Jain

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 1, Pages 321-326

The myelinated A δ (sharp pain, first pain) peripheral nociceptors and unmyelinated C
nociceptors (delayed pain, second pain) respond to strong mechanical, thermal, chemical
stimuli that act as transducers, converting chemical, mechanical or thermal energy at the site
of stimulus to electrical activity, which are conducted to the dorsal horn of CNS. Based on
previous study by Usha Bafna et al., sample size was calculated to be 30 patients, to be
randomly included in each group to demonstrate a 40% difference in duration of analgesia
with a power of 0.8 and type-1 error of 0.05. To allow for study error and attrition, 35 patients
were included in each group. In Group A, 3 (8.57%) patients and in Group B, 4 (11.42%)
showed hypotension that is mean SBP was less than 20% of the base line, were as none of
patients in either group showed hypertension that is more than 20% of the baseline SBP
(intraop and postop). There was no statistically significant difference between two groups P
value (0.6903).