Online ISSN: 2515-8260

Keywords : Oral pregabalin

A study on side effects oral gabapentin versus oral pregabalin for orthopedic surgery under spinal anesthesia

Dr. Rahul Bankapur, Dr. Preeti Lamba, Dr. Kushank Sharma

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 1, Pages 327-332

Pregabalin is a structural analogue of gamma aminobutyric acid, substituted at the 3-position;
this facilitates diffusion across the blood-brain barrier. Efficacy of pregabalin has been
proven in neuropathic pain, incisional injury, inflammatory injury. Its mechanism of action is
probably the same as gabapentin but it is more lipid soluble and has superior pharmacokinetic
profile. Due to its sleep modulating effects, it has been used as an anxiolytic. Pregabalin
increases stages III-IV sleep phases and also decreases awakening at night. Patients were
counselled regarding the tablet used in preemptive analgesia its advantages and
disadvantages, the purpose of its use, they were also explained regarding the follow up till
24hr and spinal anaesthesia procedure to be used in the study and consent was taken for the
same. Ramsey sedation score of all the patients was score = 2. None of patients complained
of dizziness in group A. Ramsey sedation score of all the patients was score = 2.2.85% (1
patient) complained of dizziness in group B.


Dr Farheen Arief, Dr Mubasher Ahmad Bhat, Dr Azhar Hussain Mir, Dr Aabid Hassan, Dr Razia Bano

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 4, Pages 5785-5799

Laryngoscopy and endotracheal intubation are an integral part of an anaesthesiologist’s contribution to patient care and are regarded as one of the core skills of anesthesiologist. A number of pharmacological measures have been used to attenuate the hemodynamic stress response associated with larngoscopy and intubation. Aim: To evaluate the effect of oral Clonidine 300 mcg vs oral Pregabalin 75 mg premedication in attenuating the hemodynamic response following laryngoscopy. Methods: The study was designed as a hospital-based prospective observational  trial involving 120 patients of ASA physical status I of either sex scheduled to undergo elective general surgical procedures under general anaesthesia. The patients were randomly allocated to three equal groups of 40 each by means of a computer-generated table of random numbers. The Heart Rate, Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP), Mean Arterial Pressure values, and arrhythmias (if any) were recorded. Statistical testing was conducted with the statistical package for the social science system (SPSS) version 17.0. Continuous variables were presented as mean±SD or median (IQR) for non-normally distributed data. Categorical variables were expressed as frequencies and percentages. Results:  The heart rate increased by 27.7% 1 min after direct laryngoscopy and endotracheal intubation compared to baseline value in the placebo group (p<0.01). A similar increase in pregabalin group was 29.9% and in clonidine group was 12.7%. The mean arterial pressure increased by 28.5% in placebo group while it increased by 26.6% in pregabalin group and only by 11.17% in clonidine group compared to baseline values during laryngoscopy and intubation. Attenuation of mean arterial pressure is significant in clonidine group as compared to both pregabalin and placebo groups (p<0.01). With regard to arrhythmia, which was our secondary objective, it was observed that none of the patients who participated in our study developed arrhythmias, either at induction or anytime later during the surgeries. Conclusion: Oral clonidine (300µg) given 120 min before induction was effective in attenuating hemodynamic stress response to laryngoscopy and endotracheal intubation. There was no statistically significant difference between placebo and pregabalin groups.