Online ISSN: 2515-8260

Keywords : Hypertensive disorders of pregnancy


SERUM URIC ACID AS A MARKER OF HYPERTENSIVE DISORDERS IN PREGNANCY: A PROSPECTIVE STUDY

Dr. Madupathi Anil Babu, Dr. Brungi Ashajyothi, Dr. Tatikonda Karuna Sree, Dr. Abhigna Sai

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 6, Pages 552-568

Background: Pregnancy-related hypertensive disorders, a condition with numerous maternal and foetal consequences, can be avoided. By measuring serum uric acid levels, the condition can be detected early on and its progression can be stopped. In India, the prevalence of PIH varies from 5% to 15%. Fetal growth restriction, low birth weight, spontaneous or iatrogenic premature delivery, respiratory distress syndrome, and admission to neonatal intensive care are all significantly linked to preeclampsia. Preeclampsia prediction may aid in classifying women into high risk groups so that surveillance can be stepped up and preventative treatments can be started.
Aim and Objectives: The purpose of this research is to investigate the role that serum uric acid plays as a predictive factor in hypertensive disorders of pregnancy. The purpose of this study is to determine the function that serum uric acid plays in the determination of hypertensive problems in pregnancy. The purpose of this study is to evaluate the accuracy of blood uric acid as a potential predictive predictor of maternal and foetal problems related with hypertensive diseases of pregnancy.
Methods: Patients with hypertensive disorders of pregnancy who came in for antenatal checkups between 24-32 weeks and had blood pressure readings of more than or equal to 140/90 mmHg but did not have proteinuria were included in a study that was conducted in the department of obstetrics and gynaecology at the Modern government maternity hospital in Petlaburz. The inclusion and exclusion criteria were met by these patients. As part of the standard evaluation, the level of uric acid in the serum was determined for each and every hypertensive patient. Recording was done for both the maternal and perinatal outcomes.
Results: In the current study, 46 (46%) of the 100 women with HDP had elevated serum uric acid levels. Of the 64 women who had pre-eclampsia, 34 (53.1%) had high serum uric acid levels. The median serum uric acid level was 6.2mg/dl, with an SD of 1.8. Numerous maternal and postnatal problems, including eclampsia, abruption of the placenta, HELLP syndrome, and foetal growth restriction, were linked to hyperuricemia in HDP patients.
Conclusion: Patients who have been given a diagnosis of hypertensive disorders of pregnancy and who also have hyperuricemia are at an increased risk for a variety of different maternal and perinatal complications.

Hypertensive disorders of pregnancy and feto-maternal outcomes in a tertiary health care centre, Koppal

Dr.Dhanalakshmi KR,Dr.Seema BN, Dr.Narayani BH

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 1, Pages 464-472

Background: Hypertensive disorders of pregnancy are known to cause adverse maternal and fetal complications and outcomes. In view of assessing its burden and feto-maternal complications and outcomes in the current study setting, the study was conducted.
Material and Methods: This is a retrospective study conducted among 8941 women with more than 20 weeks of gestation, admitted for delivery under the department of Obstetrics and Gynaecology at Koppal Institute of Medical Sciences during the study period of 2 years from July 2019 to June 2021. The primary outcome was assessed in terms of proportions of hypertensive disorders of pregnancy and eclampsia. Secondary outcomes were assessed in terms of feto-maternal complications and outcomes among those with hypertensive disorders of pregnancy. All the quantitative data were presented in percentages.
Results: The proportions of hypertensive disorders of pregnancy were 10.64% and eclampsia was noted to be 1.9%. Majority (63.1%) of the study subjects were between 18 to 23 years, mostly from rural areas (89.8%) and belonged to lower socio-economic status (95.1%). The highest proportion of them (87.9%) had crossed a gestational age of 34 weeks and also primigravida formed the majority (68.4%). None of them were booked and 41.7% of them underwent lower segment caesarian section. 5.3% of the study subjects had maternal complications with common complications being HELLP syndrome, renal complications, pulmonary edema and cerebral venous thrombosis. 0.7% of them died. 28.9% of neonates had complications viz., low birth weight, preterm and small for date babies. Intrauterine deaths were noted among 8.1%.
Conclusion: 1 in 10 mothers had hypertensive disorders of pregnancy and nearly 2 of such 100 hypertensive mothers landed in eclampsia. Feto-maternal complications were documented among 5.3% mothers and 28.9% neonates. Maternal mortality was reported in 0.7% and 8.1% of fetuses had intrauterine deaths contributing to perinatal deaths.