Online ISSN: 2515-8260

Keywords : HELLP Syndrome


Dr. Nahid Khanam, Dr. G Prasanna, Dr. Jyochnamayi Panda, Dr. Neha Khanam .

European Journal of Molecular & Clinical Medicine, 2023, Volume 10, Issue 1, Pages 4068-4079

Pregnancy induced hypertension is one of the leading medical disorder of pregnancy and contributes significantly to poor maternal and perinatal outcome. The early detection and effective management play a beneficial role in the outcome of pregnancy, both for the mother and the baby. Incidence of Pre-eclampsia is 3-6% of all pregnancies and 1.5 to 2 times higher risk in primigravida.
Materials and Methods: This study was hospital based observational prospective study from September 2020 to August 2022. Total 150 pregnant women included in the study and fetomaternal outcome were noted and statistical analysis done using SPSS-20.
Results: Majority of patients were in age group 21-25 years in both the groups i.e. 44% in study group and 46.7 % in control group. In study group around 58.7% were preterm deliveries. In our study in group A with deranged biomarkers  and group B with normal biomarkers, developed abruption placenta  in 26.7 v/s 2.7%, eclampsia in 18.7% v/s 1.3%, HELLP syndrome in 8% v/s 0%, ARF in  4% v/s0% respectively. In our study perinatal complications developed in group A and group B were IUGR (20% v/s 8%), fetal distress(37.3% v/s 20%),  NICU admission(49.3% v/s 29.3%), MSL (12% v/s 20%)  and IUD (9.3% v/s 1.3%) respectively.
Conclusion:  Hypertensive disorders of pregnancy with deranged hepatic biomarkers are correlated with more adverse maternal and perinatal complications compared to normal hepatic biomarkers. Such cases require more frequent antenatal check-ups with serial ultrasonography.

Hypertensive disorders of pregnancy and feto-maternal outcomes in a tertiary health care centre, Koppal

Dr.Dhanalakshmi KR,Dr.Seema BN, Dr.Narayani BH

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 1, Pages 464-472

Background: Hypertensive disorders of pregnancy are known to cause adverse maternal and fetal complications and outcomes. In view of assessing its burden and feto-maternal complications and outcomes in the current study setting, the study was conducted.
Material and Methods: This is a retrospective study conducted among 8941 women with more than 20 weeks of gestation, admitted for delivery under the department of Obstetrics and Gynaecology at Koppal Institute of Medical Sciences during the study period of 2 years from July 2019 to June 2021. The primary outcome was assessed in terms of proportions of hypertensive disorders of pregnancy and eclampsia. Secondary outcomes were assessed in terms of feto-maternal complications and outcomes among those with hypertensive disorders of pregnancy. All the quantitative data were presented in percentages.
Results: The proportions of hypertensive disorders of pregnancy were 10.64% and eclampsia was noted to be 1.9%. Majority (63.1%) of the study subjects were between 18 to 23 years, mostly from rural areas (89.8%) and belonged to lower socio-economic status (95.1%). The highest proportion of them (87.9%) had crossed a gestational age of 34 weeks and also primigravida formed the majority (68.4%). None of them were booked and 41.7% of them underwent lower segment caesarian section. 5.3% of the study subjects had maternal complications with common complications being HELLP syndrome, renal complications, pulmonary edema and cerebral venous thrombosis. 0.7% of them died. 28.9% of neonates had complications viz., low birth weight, preterm and small for date babies. Intrauterine deaths were noted among 8.1%.
Conclusion: 1 in 10 mothers had hypertensive disorders of pregnancy and nearly 2 of such 100 hypertensive mothers landed in eclampsia. Feto-maternal complications were documented among 5.3% mothers and 28.9% neonates. Maternal mortality was reported in 0.7% and 8.1% of fetuses had intrauterine deaths contributing to perinatal deaths.