Online ISSN: 2515-8260

Keywords : prostate specific antigen

Assessment of total PSA and free PSA levels in female patients with breast cancer

Dr. Ruhi Mahajan, Dr. Rishabh Gupta, Dr. Servishet Saraf, Dr. Jharna Verma

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 976-980

Background:Breast cancer continues to be a significant health threat, being the second
most common cancer among Indian women. The present study was conducted to assess
total PSA and free PSA levels in female patients with breast cancer.
Materials & Methods: female patients with tumours growth of breast were included.
Patients were classified into benign and malignant growth according to WHO
classification. Patients were classified into group I (breast growth) and healthy subjects
were put in group II. Parameters such as serum total prostate specific antigen (TPSA),
serum free prostate specific antigen (FPSA) was recorded.
Results: Age group 20-40 years had 30 in group I and 28 in group II and 40-60 years
had 35 in group I and 37 in group II. There were 38 benign and 27 malignant lesions of
breast. The difference was significant (P< 0.05). The mean total PSA in benign lesions
was 12.2, in malignant was 15.7 and in group II was 1.8 and free PSA was 0.15 in
benign, 0.22 in malignant and 2 in group II. The difference was significant (P< 0.05).
Conclusion: Both benign and malignant breast tumour patients exhibited high level of
free and total prostate specific antigen.

Spectrum of prostatic lesions in a tertiary care hospital, northeast of India

Swarupa Chakma, Nabaneet Majumder, Sayandeep Nath, Sanjay Nath, Tapash Rudrapaul

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 1, Pages 804-812

Introduction: Establishing or ruling out the diagnosis of carcinoma of prostate has been
a challenging task for pathologists for many years .it was an observational study where
patients who underwent TURP procedure were studied. The present study is an attempt
to understand the histopathological spectrum of prostatic lesions and study the
demographic distribution of various prostatic lesions.
Methods: The present study includes 125 cases of prostate specimen from January 2018
to September 2021 received in the post graduate department of Pathology, Tripura
Medical College. H and E stained sections were examined. The relevant clinical details
pertaining to age, clinical complaints and microscopic details are analyzed and
compared with other similar studies.
Result: Total 125 case were studied among which 69 (55.2%) cases were found to be
consistent with BPH and 24 cases were found to be malignant lesion (19.2%). 24 cases
were found to be BPH with associated prostatitis like features, consistent with benign
prostatic lesion. High grade Prostatic Intraepithelial lesions were seen in 8 cases (6.4%).
Out of the 24 malignant cases, majority had Gleason score between 8-10. Perineural
invasion was seen in 10 out of 24 malignant cases (41.6%). All malignant lesions were
adenocarcinoma and 20 were incidental carcinoma which accounted for 16% of all
prostatic lesions. Serum prostate specific antigen levels were available in 24 cases of
prostatic adenocarcinoma cases. 21 out of 24 cases had serum prostate specific antigen
levels greater than 10 ng/ml. (87.5%). Grade Group 4 had the maximum number of
cases i.e 45.8%. Out of 125 cases, 89 (71.2%) cases were from urban areas and 36
(28.8%) cases were from rural areas. All the 24 cases with prostatic adenocarcinoma
were from urban areas.