Online ISSN: 2515-8260

Keywords : alpha fetoprotein


Association between second trimester maternal serum alpha fetoprotein in 14-22 weeks and adverse pregnancy outcome

Swati Sheoran, Vini Gupta, Antima Singh

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 1, Pages 1035-1039

Background:Alpha-fetoprotein (AFP) is the major serum protein in the embryonic
stage and in the early fetal stage.This study assessed association between second
trimester maternal serum alpha fetoprotein in 14-22 weeks and adverse pregnancy
outcome.
Materials & Methods: 152 pregnancies were included in this study. Weight of the fetus
was estimated by the Honarvar 2 equation and compared with real weight. The MSAFP
levels are reported in ng/cc.
Results: Age group 18-22 years had 45, 23-27 years had 60 and 28-32 years had 47
patients. The difference was non- significant (P> 0.05). The mean MSAFP in preeclmpasia
was 76.1, in without pre-eclmpasia was 41.3, in preterm laborwas 55.2, in
without preterm labor was 41.0, in PROM was 42.7 and in without PROM was 43.8.
The difference was significant (P< 0.05). MSAFP level in oligohydramnious was 78.2, in
without oligohydramnious was 40.3, in stillbirth was 36.5, in without stillbirth was 45.2,
in miscarriage was 40.7 and in without miscarriage was 43.1. The difference was
significant (P< 0.05).
Conclusion: Pregnancies with an elevated MSAFP level are associated with adverse
obstetric outcomes.