Online ISSN: 2515-8260

Keywords : histopathological diagnosis

Renal Biopsy Profile in a Tertiary Care Referral Hospital in North Karnataka

Venkatesh Moger, Sushma Shetty, Suryakanth, Gavishiddesh Vishwanath Ronad

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 2888-2894

Background: A review of renal biopsy data gives insight into the spectrum of clinically significant renal
disease and necessary epidemiological data on renal diseases. Objectives: to analyze the
histopathological spectrum of native kidney biopsies in the north Karnataka population.
Material & Methods: A total of 772 patients who underwent kidney biopsies at Department of
Nephrology KIMS Hubli from January 2000 to December 2020 were included in the study. Results: The
mean age of patients was 36.77+25.15 years. The most common histopathological diagnosis made was of
primary glomerular disease (57.77%), followed by Tubulo-interstitial disease(17.61%), while the least
common was the vascular disease (1.8%). Glomereular disease is the most common histopathological
finding among renal biopsies. Among primary glomerular diseases Minimal change disease was the most
common finding noted in 23.31% of cases followed by Focal segmental glomerulosclerosis(18.16%),IgA
nephropathy (14.57%),Membranous GN(11.88%), Membrano proliferative GN(10.98%),
Mesangiocapillary GN (10.76%),Complement mediated GN (5.1%), Crescentic GN21 (4.7%), IgM
nephropathy (0.4%)was the least common finding among glomerular diseases.
Conclusion: a wide variation of major histological groups in the primary glomerular diseases has been
observed with most common being minimal change disease. However, among most countries of tHE
world, the most common secondary glomerular disease has been documented as LN.

MDCT imaging features with the histopathological diagnosis of carcinoma esophagus

Dr. Rashwin Pinto, Dr. Pradeep Kumar CN, Dr. Rinu Pious, Dr. Lohith K, Dr. Supriya AS

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 2, Pages 2463-2472

Early oesophageal cancer has shown a good 5-year survival rate of 57%-78%. Its high mortality rate makes it a major concern. Overall survival rate is 62.5% at 1 year, 42.4% at 2 years and 30% at 5 years. The prognosis is poor in locally advanced diseases and worse in cases with distant metastasis. Squamous cell carcinomas (SCCs) and adenocarcinomas are the most common oesophageal cancers. Patients with the signs and symptoms relating to dysphagia, weight loss, and/or hematemesis were referred from various Departments. Out of all these patients, 78 patients were selected on the basis of histopathological examination (HPE) report showing the confirmed presence of carcinoma of the esophagus. All the patients with upper third growths (14 patients, 24.6%) had squamous carcinoma while 25 out of 28 patients (44%) had middle third growths had squamous carcinoma and 18 out of 36 patients (31%) with lower third growths had SCC. Adenocarcinoma was observed to be seen maximum in lower third location (85.7%). Squamous cell carcinoma was observed to be seen maximum in the middle third location (43.9%) followed by lower third location (31.6%). Adenocarcinoma was observed to be seen maximum in lower third location (85.7%). Squamous cell carcinoma was observed to be seen maximum in middle third location (43.9%) followed by lower third location (31.6%).

Mucormycosis in COVID: A pandemic induced epidemic in World’s diabetic capital

Dr Fayaz A. Wani, Dr Ishan Tikoo, Dr Aashish Mahajan, Dr JB Singh, Dr Deepika Dewan

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 1, Pages 1051-1058

Background: Mucormycosis is a rare disease of immunocompromised adults largely
restricted to the diabetic community with uncontrolled hyperglycaemia. In the second
wave of Covid, in multiple cities over the Indian Peninsula, this much dreaded “black
fungus” has afflicted many individuals who suffered from covid or were recovering
from it.
Aim: To establish the risk factors, clinical presentation, diagnostic sensitivities,
radiological survey of different types of mucormycosis in SARS Cov 2 patients.
Methods: Seventeen patients with covid infection admitted in tertiary care hospital with
diagnosed mucormycosis between Nov 2020 to June 2021 via histopathological or
culture confirmation. This is a cross-sectional observational study where detailed
assessment of clinical profile, biochemical markers and sensitivities of diagnostic
procedures was done. The data then collected and was made into a master chart and
subjected to statistical analysis. Fischer exact test was used for statistical anaylsis.
Result:In total of 17 patients,mean blood glucose levels were compared at the onset of
symptoms of covid and mucormycosis werestatistically significant with (P=0.001). Out
of 17 patients, 11 were rhino-orbital mucormycosis, four had rhino-orbito-cerebral
mucormycosis and 2 had pulmonary mucormycosis.HbA1c >8 had significant
correlation(P=0.009) with rhino-orbital and rhino-orbito-cerebral mucormycosis
whilehigher total dosage of steroids was associated with pulmonary mucormycosis (P=
0.015. Sensitivity of culture was 64.7% in our study while histopathology was
considered gold standard.
Conclusion: Our study shows strong correlation between the long term as well as short
term glycaemic control with the onset of rhino-orbital mucormycosis while dosage and
duration of steroids with pulmonary mucormycosis.

A cross-sectional prospective assessment of the sonographic morphology of pelvic masses and its correlation with the histopathological diagnosis

Dr. Govind Khatri, Dr. Monika Sharma, Dr. Aditya Kaul, Dr.Ankitaa Thakral, Dr. Pratibha Gupta, Dr. Naresh Tripathi

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 1, Pages 1142-1150

Aim: To evaluate the sonographic morphology of pelvic masses and to correlate with the
histopathological diagnosis of the patients who underwent surgical intervention.
Material and Methods: A cross-sectional prospective study was conducted in the
Department of Radiology Maharishi Markandeswar Medical College and Hospital
Kumarhatti, Solan,Himachal Pradesh for the period of 1 year. Total 100 female patients with
Gynecological masses using high resolution ultrasonography and findings correlated with
histopathology or serial sonographic examination.
Results: Majority of the patients were in the age group of 40-50 years with mean age of 36.3
years. The minimum number was in the age group of below 20 years. The most common
chief complaint of female patients enrolled in our study was pelvic pain 36 (36%) followed
by pain and palpable mass 16(16%).Menstrualirregularity, menorrhagia, post-menopausal
bleeding, infertility, and amenorrhea were the other less common complaints in the female
patients of our study. Out of 100 patients evaluated by ultrasonography 25 (25%) were having
ovarian pathologies and 45(45%) were having uterine pathologies. Eleven patients presented
with localized collection in the fallopian tube pathologies. Few cases there were involvement
8(8%) of vagina. Fibroids were the most common uterine masses.
Conclusion: The USG is most commonly preferred imaging tool to evaluate gynecological
masses. It’s important to differentiate gynecological and non-gynecological masses on
sonography for accurate management of the patient.