Online ISSN: 2515-8260

Keywords : prostrate


Elastography plus MRI image-based TRUS biopsy versus extended core biopsy for prostate cancer detection and diagnosis

Dr. Kothapalli Jitender Reddy, Dr. Peddi Raju

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 7, Pages 2161-2165

Aim: The comparison of diagnostic accuracy for prostate cancer detection between elastography plus MRI image based TRUS biopsy versus extended core biopsy.
Methods: This Comparative study was carried out in the Department of Radio Diagnosis, RVM Institute of Medical Sciences & Research Centre for the period of 9 months. 50 Patients with age group of 35 to 75 years, with Serum PSA greater than 4.0 ng/dl were included in this study. All patient underwent TRUS biopsy based on the MRI and elastography images, followed by TRUS guided extended core biopsy (13 cores) done by radiologist randomly. The rate of prostate cancer detection was compared between the two types of biopsies. Group A consisted of cores from MRI plus Elastography guided TRUS biopsy and Group B were cores from extended core biopsy.
Results: The mean age of patients was 64.71. The mean serum PSA for patients was 14.70 ng/dl (6.5 to 40.7). 20 cases presented with AUR and patients were catheterized. The mean size of prostate was 51.07 mg (29 to 84 mg). The mean size of prostate and serum PSA of patients with carcinoma prostate were 14.1 mg and 18.4ng/dl respectively. Prostatic carcinoma detection with extended core biopsy was 42% (n=21). The incidence of prostate cancer detection by MRI plus Elastrography guided TRUS is 41 cases (82%). MRI plus Elastrography guided TRUS biopsy method is considered to be statistically significant as the p value is 0.0369 (since p<0.05) as obtained by fishers exact test. In our study majority of the patients had adenomatous hyperplasia (n=30,60%) as the HPE diagnosis, followed by adenocarcinoma (n==20,40%). The sensitivity of mpMRI plus Elastography image based TRUS biopsy method in detecting Prostate cancer was 84.5% and specificity was 82%. The positive predictive value of this method was found to be 80%.
Conclusion: Even while mpMRI and Elastography are each useful alone for detecting prostate cancer, using both diagnostic methods together for TRUS guided enhances the likelihood of cancer diagnosis over extended core biopsy.

Prostate cancer Detection and Diagnosis: Elastographyplus MRI image-based TRUS biopsy versus extended core biopsy

Dr. Sidhant Lochav, Dr.Varsha Gangta, Dr. Aditya Kaul,Dr. Bhavika Jakhu, Dr. Venus Garg, Dr. Govind Khatri

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 1, Pages 1119-1123

Aim: The comparison of diagnostic accuracy for prostate cancer detection between
elastography plus MRI image based TRUS biopsy versus extended core biopsy.
Methods: This Comparative study was carried out in the Department of Radio Diagnosis,
Maharishi Markandeshwar Medical College and Hospital, Kumarhatti, Solan, Himachal
Pradesh, India for the period of 6 months. 50 Patients with age group of 35 to 75 years, with
Serum PSA greater than 4.0 ng/dl were included in this study. All patient underwent TRUS
biopsy based on the MRI and elastography images, followed by TRUS guided extended core
biopsy (13 cores) done by radiologist randomly. The rate of prostate cancer detection was
compared between the two types of biopsies. Group A consisted of cores from MRI plus
Elastographyguided TRUS biopsy and Group B were cores from extended core biopsy.
Results: The mean age of patients was 63.71. The mean serum PSA for patients was 14.77
ng/dl (6.5 to 40.7). 20 cases presented with AUR and patients were catheterized. The mean
size of prostate in all 50 patients was 51.77 mg (29 to 84 mg). The mean size of prostate and
serum PSA of patients with carcinoma prostate were 14.9 mg and 18 ng/dl respectively.
Prostatic carcinoma detection with extended core biopsy was 42% (n=21). The incidence of
prostate cancer detection by MRI plus Elastography guided TRUS is 41 cases (82%). MRI
plus Elastography guided TRUS biopsy method is considered to be statistically significant as
the p value is 0.0369(since p < 0.05) as obtained by fishers exact test. In our study majority of
the patients had adenomatous hyperplasia (n=30,60%) as the HPE diagnosis, followed by
adenocarcinoma (n==20,40%). The sensitivity of mpMRI plus Elastography image based
TRUS biopsy method in detecting Prostate cancer was 84.5% and specificity was 82%. The
positive predictive value of this method was found to be 80%.
Conclusion: Although mpMRI and Elastography are individually useful for detection of
prostate malignancy, combining both the diagnostic tools for TRUS guided increases the rate
of cancer detection than that of extended core biopsy.