Online ISSN: 2515-8260

Keywords : Phototherapy


Effect of phototherapy on serum electrolytes in neonatal hyperbilirubinemia

Dr. Shrdha Sharma, Dr. Rajeev Vinayak, Dr. Rita Hajela

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 2, Pages 1-9

Introduction: Neonatal hyperbilirubinemia is the most common clinical finding noted during
the first seven days following birth. Amongst all the modalities available for management of
neonatal hyperbilirubinemia, phototherapy is proven to be the safest. However, like any other
intervention, phototherapy too has some of its own side effects.
Aim & objectives: To estimate and compare alterations in serum electrolytes of healthy term
neonates before and after phototherapy.
Material & methods: A hospital based prospective observational comparative study was
conducted over a period of 18 months in the department of Pediatrics on 110 healthy term
neonates with unconjugated hyperbilirubinemia who were subjected to phototherapy as per
American Academy Pediatrics guidelines. Electrolytes including sodium, potassium, chloride
and calcium were analyzed from serum using standard laboratory techniques.
Results: The mean sodium, chloride, potassium and calcium levels before phototherapy was
141.3±2.69 meq/L, 102.2±2.98 meq/L, 4.43±0.52 meq/L, 9.14±0.46 mg/dl and after
phototherapy was 140.5±2.70 meq/L, 102.0±2.93 meq/L, 4.23±0.48 meq/L and 8.09±0.55
mg/dl respectively. All were found to be statistically significant (p-value <0.05); although none
were clinically significant and conveyed no symptom of dyselectrolytemia in this study.
Conclusion: This study shows that neonates exposed to phototherapy are at a risk of
developing electrolyte imbalances and consequently their complications. Hence, close
monitoring of such babies are needed to prevent imbalances and their untoward consequences.

Efficacy of fractional CO2 laser, NB-UVB and .05% clobetasol propionate vs NB-UVB and .05% clobetasol propionate in patients with vitiligo: A comparative study

Dr Manish Choudhary, Dr Rajkumar Kothiwala

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 1027-1031

Background: Conventional vitiligo treatment on the hands and feet frequently yields
disappointing results. In the face, neck, and truncal areas, various ablative therapy
approaches were tested with positive results.
Material and methods: On 44 individual patients in each group with 44 pair-lesions of
non-segmental vitiligo on both hands, a prospective randomized study was done. In
(Group A) treatment with fractional CO2 laser, NB-UVB phototherapy, and 0.05 %
clobetasol propionate cream and NB-UVB phototherapy and 0.05 % clobetasol
propionate cream was given (Group B). For ten sessions, fractional CO2 laser was used
at four week intervals. NBUVB phototherapy was given twice a week for a total of 20
sessions. Twelve weeks following the last therapy, the patients were assessed. Standard
digital pictures, patient satisfaction, and adverse events were used to assess the
outcomes.
Results: Patients' satisfaction with lesions in group A was much higher than that of
group B. Lesions on dorsal surfaces of hands responded more quickly than those on
ventral surfaces.
Conclusion: In some individuals, combining fractional CO2 laser treatment with NBUVB
phototherapy and topical steroids enhances repigmentation in vitiliginous lesions
on the hands. Patients with vitiligo who have not responded to conventional therapies
may be offered this procedure.