Online ISSN: 2515-8260

Keywords : Prognostic Marker in Stroke


A study of C-reactive protein in cerebrovascular accident (stroke) in a tertiary care hospital

Dr. Pinniboyana Vijaya Kumar, Dr. Pinniboyana Sri Harshitha, Dr. Gridhati Srinivas

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 1, Pages 1288-1293

Background: Stroke is the top cause of death and one of the leading causes of long-term
disability all over the world. hsCRP levels evaluated shortly after a stroke have been
demonstrated in studies to predict complementary elements of outcome. There's a
chance that high hsCRP levels are linked to the severity of cerebral tissue damage. We
wanted to see how high hsCRP levels were in people who had a cerebrovascular
accident. The goal was to see if there was a link between the level of hsCRP and the
severity of the stroke and the outcome.
Material and Methods: Patients hospitalised to a tertiary care hospital's (Narayana
Medical College Nellore) medical ward and medical ICU were studied. It was a crosssectional
investigation. The study involved a total of 100 patients who had a stroke and
met the study's inclusion and exclusion criteria. hsCRP levels were tested in all patients
within 48 hours of admission. Data was entered into a Microsoft Excel database
prospectively.
Results: The average age of the patients in the study was 59.12 years. Eighty-eight
percent of the patients were between the ages of 40 and 80. Also, values were found to
be higher in haemorrhagic stroke (value) than ischemic stroke (value), with a significant
difference. In both types of stroke, there was a significant association between hsCRP
levels and GCS, with lower GCS scores linked with greater hsCRP levels.
Conclusion: We concluded that hsCRP levels are elevated in both ischemic and
hemorrhagic strokes, implying an inflammatory response in acute stroke. Increased
hsCRP levels were linked to the degree of the neurological impairment and a worse
prognosis.