Online ISSN: 2515-8260

Keywords : Gestation


PREDICTION OF HYPERTENSIVE DISORDERS IN EARLY TRIMESTER OF PREGNANCY

Dr. Shashi Jyothsna Parlapally, Dr. Vanitha CH, Dr. Pilli Rajitha

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 5, Pages 21-30

Background and objectives: Predicting preeclampsia (PE) at 11-14 weeks of gestation is a new concept. Studies integrating multiple factors at 11-14 weeks of pregnancy have been conducted, but an algorithm with a good predictive value has yet to be created. This study aimed to design a methodology combining MAP, Uterine artery Doppler, and PAPPA at 11-14 weeks of pregnancy to predict PE in India. Basically objective is to determine whether higher Mean Arterial Pressure (MAP), increased Uterine Artery Pulsatility Index (UAPI), and low Pregnancy Associated Plasma Protein A (PAPP - A) between weeks 11-14 of pregnancy are linked to the growth of hypertensive diseases in pregnancy.
Method: This is a prospective cohort study. Data were obtained from 200 registered patients attending antenatal OPD in hospitals between 11 and 14 weeks of gestation. MAP, blood pressure, uterine artery Doppler, and serum sample for PAPPA were measured. IBM SPSS Version 22 for Windows was used to analyse the data.
Result: There were a total of 200 women enrolled in the study, and 24 of those women (37.1%) suffered difficulties. At 11-14 weeks of pregnancy, the uterine artery doppler pulsatality index (PI) was found to be an effective screening tool (sensitivity 29%, specificity 90%) for the prediction of pregnancy.
Conclusion: This study revealed that the uterine artery Doppler Pulsatality index is an effective screening approach for women at high risk of developing preeclampsia and related complications during the 11th to 14th week of pregnancy.
 

Ultrasonographic correlation of placental thickness in third trimester with fetal parameters, birth weight and fetal outcome

Dr. Nikhil Arora, Dr. Sahil Arora, Dr. Yashaswi Sharma, Dr. Navkiran Dhanota, Dr. Priyanka Arora, Dr. Sanjeev Sharma

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 2, Pages 72-77

Introduction: Despite careful antenatal surveillance involving scrupulous examination, an issue of
considerable disappointment is that a majority of low-birth-weight infants are not diagnosed until
delivery. Low birth weight infants are susceptible to hypoxia and fetal distress, long-term handicap, and
fetal death.
Objectives: The present study will be undertaken in our institution to study the correlation of placental
thickness, measured at the level of the umbilical cord insertion, with the ultrasonographic gestational age
in normal women and fetal weight and outcome.
Methods: Present study was a single centric, observational, cohort, follow up, hospital-based study in
which 100 pregnant women who will come for ultrasound in third trimester during the study period was
recruited in the study. The relationship between placental thickness with fetal parameters, birth weight
and fetal outcome at delivery was investigated in this study. Correlation between placental thickness with
the fetal parameters, average gestational age, gestation at delivery, neonatal birth weight & APGAR
score, and placental weight was investigated during this study.
Results: Significant positive correction of placenta thickness was found with the gestation age, estimated
and actual fetal birth weight, and placenta weight. APGAR score showed negative correlation with the
placenta thickness. Positive correlation of placenta thickness was also found with the Biparietal diameter
(BPD), Head Circumference (HC), abdominal circumference (AC) and Femur length (FL).
Conclusion: Ultrasonography serves a significant role in estimating foetal weight, which is a crucial
component of prenatal care. Because of its linear association, placental thickness evaluated at the level
of umbilical cord insertion can be utilised as a reliable sonographic indication in the evaluation of. As a
result, it can be utilised as a secondary sonographic method for determining foetal weight.