Online ISSN: 2515-8260

Keywords : Malignant Lesions


To study immune histochemical expression of CD34 and CD117 in benign and malignant prostaticlesions

Dr. Asha Jyothi. T, Dr. C. Aruna

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 7-20

ToevaluateandcomparetheexpressionpatternsofCD34andCD117inbenignandmalignantp
rostatictissuesandtheirrelationtotheclinicopathologicalfeatures.
Methodology:The present study has been conducted at Department of Pathology,
atOsmaniaGeneralHospitalfromAugust2017toJuly2019.total100caseswerecollected.Rout
ineprocessingandHaematoxylinandEosinstainingofreceivedspecimensweredonefollowed
byimmunohistochemicalanalysiswithCD34andCD117.

To study the histopathological spectrum of prostatic lesions and to classify them as benign, with associated inflammation, premalignant and malignant

Dr. Priyanka Rani, Dr. Francis K Sridhar, Dr. Rupinder Kaur, Dr. Nalini Calton, Dr. Shekhar Baweja

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 2704-2712

Background: Gleason's system is now widely being utilized as the histologic grading system for prostatic cancer and is a powerful predictor of cancer behaviour.The present study was conducted to analyse the histopathological spectrum of prostatic lesions and to classify them as benign, with associated inflammation, premalignant and malignant.
Material and methods: The sample size was 302. Collected data was analyzed with descriptive statistics followed by chi- square test. Tests were used to analyze diagnosing benign and malignant prostatic lesions. p value was calculated and considered statistically significant when p value was less than 0.005.
Results: Out of 302 specimens, 72.5% were of BPH, 1% of PIN and 26.5% were of Adenocarcinoma.  Majority (40.1%) of patients were in 7th decade (BPH) followed by in 8thdecade (33.4%) in adenocarcinoma. Of the total cases, majority of the specimens received were of TURP chips (74.8%). Most of the patients had grade II prostatomegaly on clinical examination in benign cases and grade IV in malignant cases. Out of 85 benign cases, majority (83 cases) had firm prostate. Of the 39 malignant cases, 33 prostates were hard and 6 were firm in consistency. Most of the patients (63.6%) in our study presented with acute and chronic urinary retention, increased frequency, poor urinary stream. Most common Gleason score in our study was 7(33.7% cases).
Conclusion: The present study concluded that out of 302 prostatic specimens studied, benign lesions were common, accounting for 72.5% and malignant lesions accounted for 26.5%.

Histomorphological patterns of various kidney lesions in nephrectomy specimens in a tertiary care hospital

Megha Bansal, Ritu Sharma, Nikhilesh Kumar, Ram Kishore Rathore

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 10722-10727

Introduction: Kidneys are one of the major organs of the human body that serve several
essential functions. Kidneys are affected by various nonneoplastic and neoplastic
pathological processes. Nephrectomy is a surgical procedure done for wide variety of
conditions like chronic pyelonephritis, calculi, malignancy, injury etc.
Aim: To study the histomorphological pattern of various kidney lesions in nephrectomy
specimens received in the department of pathology in our institute.
Materials and Methods: This was a retrospective study carried out in department of
pathology in TSM medical college Lucknow from March 2018 to April 2020. A total of
45 nephrectomy specimens received during the period were included in the study.
Paraffin blocks and slides along with case records were retrieved and studied.
Results: Out of 45cases, 34 cases (75.5%) were benign and 11 cases (24.5) were
malignant. Age ranged from 3 years to 75 years. Maximum number of cases was seen in
51-60 years of age (22%). Majority of cases were of chronic pyelonephritis (31%). Renal
cell carcinoma constituted 8 cases (17.8%). Commonest variant was clear cell
carcinoma. Wilms tumour was the commonest renal tumour in children.
Conclusion: Benign lesions of kidney outnumber the malignant lesions. Chronic
pyelonephritis was the most common histopathological diagnosis. Renal Cell Carcinoma
was the most common malignant lesion in adults. Clear cell variant was the commonest.
Wilms tumor was the commonest renal tumor in children.