European Journal of Molecular & Clinical Medicine

Background: When degenerative spinal illnesses result in neuropathic backache, nerve root decompression with instrumented interbody fusion is the preferred treatment for these groups of patients.
Methods: A hospital-based, comparative, retrospective analysis of patients who had transforaminal lumbar interbody fusion (TLIF) with either a cage with bone graft or a stand-alone autologous morselized bone graft was conducted. The clinical and radiological outcomes of these two interbody fusion procedures were evaluated to see if there was a meaningful difference. A total of 20 patients with lumbar canal stenosis and degenerative grade 1/2 spondylolisthesis who had failed conservative management were operated on using the TLIF approach and were evaluated for postoperative improvement in the Oswestry disability index (ODI) and interbody fusion on imaging at 6 months and 1 year after surgery. Each patient's vertebral level of surgical intervention, intra-operative blood loss, and operation duration, as well as any complications, were noted.
Results: There was no significant difference in clinical or radiological result between the two modalities of interbody fusion in our study. Although the group that received morselized bone graft with cage had a somewhat better clinical outcome at 6 months, there was no meaningful difference in ODI at 1 year.
Conclusions: Based on the findings of this study, we can infer that both procedures have similar clinical and radiological outcomes, as well as similar patient satisfaction, and can be used interchangeably for interbody fusion depending on the surgeon's and patient's preferences.

Introduction: In India, there is a high frequency of ALD, with alcohol being responsible for roughly
half of all instances of cirrhosis. However, not everyone who consumes alcohol develops the condition,
and the total chance of acquiring the disease in a person is determined by a number of variables. The
length, amount, and kind of alcohol ingested, as well as nutritional state, comorbid illnesses, sex, race,
and hereditary variables, may all have a role. Multiple investigations on the impact of drinking patterns
in the development of illness have shown conflicting conclusions.
Objectives: Present study aims towards analysing the clinical profile of patients with alcoholic liver
disease. Present study also aims to perform psychiatric screening using CAGE criteria and alcohol use
disorder identification test (AUDIT) scale for assessing the severity of alcohol dependence.
Methods: Present study was a single centric, prospective, observational and hospital-based study. 50
patients with clinical/investigational evidence of alcoholic liver disease were include in study. CAGE
Criteria to screen and alcohol use disorder identification test (AUDIT) scale was used for assessing the
severity of alcohol dependence.
Results: The mean age of the recruited patients was 50.80 ± 12.74 years. Among total 50 patients, 96%
patients were males and 4% of patients were females. Total 26% patients have CAGE score of four, 34%
patients have CAGE score of three, 40% patients have CAGE score of two whereas no patient had a
CAGE score of zero. AUDIT scoring indicate that 96% patients exhibit alcohol dependence, 4% patients
presented with harmful or hazardous drinking levels whereas no patient presented with Low-risk
consumption. A total of 96% patients were alive whereas mortality occurs in 4% patients in present study.
Conclusion: Our findings show a link between the type, amount, and duration of alcohol consumption
and the development of alcoholic liver disease.