Online ISSN: 2515-8260

Keywords : dithranol

A comparative study of efficacy and safety of topical calcipotriol and topical dithranol in chronic plaque psoriasis

Yadav Nihal, Prabhakar M Sangolli, Adarsh Gowda

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 2, Pages 325-331

Background: Psoriasis is chronic inflammatory dermatosis with genetic background. Topical therapy
alone is effective in localized psoriasis
Objective: Study was conducted to compare the efficacy and safety of topical calcipotriol and dithranol
in mild chronic plaque psoriasis with less than 10% BSA involvement
Methods: Study duration was 6 weeks. Thirty patients each were included in two groups. In calcipotriol
group, patients applied calcipotriol ointment (0.005%) twice daily. In dithranol group patients applied
1% ointment in 1st week, 2% ointment during 2nd week, 3% ointment from 3rd weeks onwards. Duration
of application was 60 minutes, once daily.
Results: Patients responded to both the treatments satisfactorily. However, calcipotriol was superior in
efficacy. Patients in both the groups tolerated the treatment.
Conclusion: Both calcipotriol and dithranol (short contact therapy) were effective in the treatment of
mild chronic plaque psoriasis. Even though, dithranol is less potent, it is cost effective.