Online ISSN: 2515-8260

Keywords : Mean Platelet Volume


STUDY OF ROLE OF PLATELET COUNT AND MEAN PLATELET VOLUME IN EVALUATING THE DISEASE SEVERITY IN COVID 19 INFECTION-OUR EXPERIENCE AT TERITARY CARE HOSPITAL

A.Smitha Reddy, B.V. Anuradha Devi, Swarupa Ravuri, B. Nageshwar Rao, Danda Samyukta Reddy, Anunayi Jestadi

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 7, Pages 185-192

INTRODUCTION: Patients Infected with CORONA VIRUS- 2019 (COVID-19) showed changes in their platelet counts and Mean platelet volume (MPV). The present study was aimed to observe any association between lowered platelet counts with mean platelet volume (MPV) from the corana positive individuals.
METHODS: It is a prospective study from 1-8-2020 to 30-9-2020 .Patients  who presented with complaints of Fever, sore throat, body pains, cough, breathlessness, diarrhoea were evaluated at the triage area of the Hospital. Throat swab was taken and RT-PCR was done and only 200 confirmed cases were included in the study. Patient blood samples were collected and processed in SYSMAX 5 -part Haematology analyser in the Hospital Central Laboratory. The patients CBP, Platelet count and MPV were tabulated.
RESULTS: Out of 200 COVID-19 confirmed cases, the numbers of males were 145 (72.5%) and females 55 (27.5%). Most of the patients belonged to age group 50 years (25.5%), 60yrs age group (21%).  The Maximum age in our study group was 80 years, minimum age was 19 years and mean age was 50 years. In our study it was noticed that Severe thrombocytopenia was seen in one patient with platelet count 38,000/μL,(0.5%), Moderate thrombocytopenia was seen in two patients(1%) and mild thrombocytopenia  was seen in 12 (6%) cases. In our study only fifteen cases (7.5%) showed thrombocytopenia. The MPV for all fifteen cases were studied and MPV was in Range of 9.6- 11.8 fl.
CONCLUSION: Low platelet count and high MPV are associated with disease severity. Platelet count is one of easy cheap method for the assessing the disease severity along with other parameters 

Mean platelet volume to lymphocyte ratio as a novel marker for diabetic nephropathy

Dr Rakesh Chander, Dr Jyoti Thakur, Dr Shivika Aggarwal, Dr Ritu Sharma, Dr Kashmir Singh

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 7, Pages 4086-4091

Aims: The present study was designed to compare Mean platelet Volume to Lymphocyte ratio (MPVLR) as predictor of inflammatory marker in patients with Diabetic nephropathy and diabetics without nephropathy.
Materials & methods: The study was conducted on 50 diabetic patients with nephropathy and 50 diabetics without nephropathy that presented to Medicine department (indoor/ outdoor department) of Guru Nanak Dev Hospital, Amritsar. The subjects were divided into two groups i.e. Group A and Group B. Group A comprised of 50 Diabetic patients with Nephropathy and Group B comprised of Diabetic patients without Nephropathy. Detailed history was taken and all patients underwent a detailed clinical evaluation including measurement of vitals. Plasma glucose, Blood urea, Serum creatinine were estimated by standard protocols. Urine complete examination was done microscopically. Albuminuria, which is the hallmark of diabetic nephropathy, was estimated using spot Urinary Albumin-creatinine ratio (UACR). The quantitative determination of microalbuminuria was done by Nephelometry method procuring commercially available kits. Mean Platelet Volume (MPV) and Absolute Lymphocyte Count (ALC) were calculated using cell counter (ABX Pentra 80) and then ratio was calculated by dividing MPV to ALC.
Results: In Group A, mean MPV was 10.46 fL while in Group B, it was 8.60 fL. The mean MPV in Group A was significantly higher as compared to Group B (p = 0.001). Mean Absolute Lymphocyte count (ALC) in Group A was 2.03x10^3/µL, while in Group B was 2.80x 10^3/µL. The mean MPVLR was 5.27 and 3.08 in Group A and Group B respectively and the difference was found to be statistically significant (p=0.001).
Conclusion: MPVLR values are higher in patients with diabetic nephropathy and this difference is statistically significant. MPVLR is easily available; cost effective and routinely done, hence, it can be considered as a novel marker for Diabetic nephropathy (DN)in diabetic patients

A cross-sectional study to assess difference of mean platelet volume among diabetics (case) and non-diabetics (control) in Western Rajasthan

Dasrath Kumar Meena, Ashok Kumar Kachhawaha, Ramesh Kumar Choudhary, Rahul Kumar, Naveen Kishoriya

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 4, Pages 3481-3486

Background: Diabetic patients have an increased risk of developing micro- vascular and macro vascular disease, and platelets may be involved as a causative agent with respect to altered platelet morphology and function. Aim of our study was to determine if platelets were activated in diabetes and to see if there was a difference in MPV in diabetics and non-diabetics.
Methodology: A cross sectional study had been conducted to study the impact of HBA1C on mean platelet volume in Type 2 diabetic patients in western Rajasthanattending the Medicine Outdoor and indoor at M.D.M. Hospital Jodhpur.
Conclusion: Platelets in Diabetes Mellitus become more reactive and agreeable and their Mean Platelet Volume (MPV) is increased. Increase in platelet size may be the one factor responsible for microvascular complication in Diabetes Mellitus. Hence, MPV could be a useful prognostic marker of micro vascular complications.

A cross-sectional study to find out association of mean platelet volume and development of microvascular complication in diabetics in Western Rajasthan

Ashok Kumar Kachhawaha,Dasrath Kumar Meena,Naveen Kishoriya, Rahul Kumar,Ramesh Kumar Choudhary

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 4, Pages 3487-3495

Background: Diabetic patients have an increased risk of developing micro- vascular and macro vascular disease, and platelets may be involved as a causative agent with respect to altered platelet morphology and function. Aim of our study was to determine if platelets were activated in diabetes and to see if there was a difference in MPV in diabetics and non-diabetics.
Methodology: A cross sectional study had been conducted to study the impact of HBA1C on mean platelet volume in Type 2 diabetic patientsand to find out association of mean platelet volume and development of microvascular complication (neuropathy, nephropathy andretinopathy) in diabetics in western Rajasthanattending the Medicine Outdoor and indoor at M.D.M. Hospital Jodhpur.
Conclusion: Platelets in Diabetes Mellitus become more reactive and agreeable and their Mean Platelet Volume (MPV) is increased. Increase in HbA1c concentration is directly proportional to increased MPV, thus poor glycemic control causes increase in MPV which result in more chance of developing microvascular complication. However, the increased MPV as the cause or the end result of microvascular complications needs to be further explored. Hence, we propose that MPV can be used as simple and cost effective tool to monitor the progression and control of Diabetes Mellitus and its associated microvascular complications.

“COVID-19 AND LOW PLATELET COUNT-A RELATIONSHIP”

DR.SHAILZA, DR. AMARJEET SINGH VERMA, DR. JYOTI SINGH RAJPUT .

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 766-771

BACKGROUND
Easily accessible, inexpensive, and widely used laboratory tests that demonstrate the severity of COVID-19 are important. Therefore, in this study, we aimed to investigate the relationship between mortality in COVID-19 and platelet count, Mean Platelet Volume (MPV), and platelet distribution width.
METHODS
In total, 100 COVID-19 patients were included in this study. The patients were divided into two groups. Patients with room air oxygen saturation < 90% were considered as severe COVID-19, and patients with ≥90% were considered moderate COVID-19. Patient medical records and the electronic patient data monitoring system were examined retrospectively. Analyses were performed using the SPSS statistical software. A p-value <0.05 was considered significant.
RESULTS
The patients’ mean age was 64,32 ± 16,07 years. According to oxygen saturation, 38 patients had moderate and 62 had severe COVID-19. Our findings revealed that oxygen saturation at admission and the MPV difference between the first and third days of hospitalization were significant parameters in COVID-19 patients for predicting mortality. While mortality was 8.4 times higher in patients who had oxygen saturation under 90 % at hospital admission, 1 unit increase in MPV increased mortality 1.76 times.
CONCLUSION
In addition to the lung capacity of patients, the mean platelet volume may be used as an auxiliary test in predicting the mortality in COVID-19 patients.

Relation of Mean Platelet Volume with Diabetic Retinopathy in Diabetes Mellitus Type 2 Patients

Sushma S Biradar,Krupashree G, ,Mohammed Nizamuddin Attar , Manjunath Hiremani

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 10039-10048


Background: Diabetic retinopathy (DR) is one of micro vascular complications of Diabetes
mellitus and leading cause of blindness. Mean Platelet volume is a marker of average size and
activity of platelets. Larger platelets are younger and exhibit more activity and related to these
complications.Objective:to study the association between mean platelet volume and Type 2
Diabetes, and its correlation with diabetic retinopathy.Methods: In this study, 100 patients with
Type 2 diabetes and without retinopathy, 50 patients with type 2 diabetes and with diabetic
retinopathy and 50 healthy age and gender matched controls were chosen and evaluated
clinically and laboratory data including MPV, platelet count,HbA1C,Fasting and post prandial
blood glucose, lipid profile,creatinine levels were obtained and studied. All study was done by
SPSS software. Results: Mean MPV among subjects with DM with Retinopathy was 11.7 ± 1.3,
among subjects with DM without Retinopathy was 10.7 ± 0.9 and among normal controls was
8.8 ± 0.5. There was significant difference in MPV b/w 3 groups. In the study there was
significant positive correlation between MPV and duration of DM, FBS, PPBS and HbA1c i.e.
with increase in Duration of DM, FBS, PPBS and HbA1c there was increase in MPV and vice
versa

Correlation of Mean Platelet Volume with Subclinical Hypothyroidism at Tertiary Care Hospital

M M Basavaraju, Sumaiya Anjum, Thejashwini A, Anoop Cheriyan

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 139-145

Background:Subclinical hypothyroidism (SH) is defined as elevated serum levels ofTSH
with normal levels of free T4 (fT4) and free T3 (fT3). The prevalence of SH has been
reported to be 4–10% in general population. Since it is generally asymptomatic, these
patients are mostly identified through routine screening or evaluation of non specific
symptoms. About 2–5% of patients progress to overt hypothyroidism annually.
Objectives: To study the mean platelet volume in patients with subclinical
hypothyroidism and to study the association between MPV and CAD in patients with
subclinical hypothyroidism.
Material &Methods:We studied 89 subclinical hypothyroid subjects and estimated
theirMean platelet volume and their cardiovascular function by ECG and 2D ECHO
and then analyzed the data.
Results:MPVwas high (>11fl) in 75.3% of subclinical hypothyroid and MPV has
significant positive correlation with TSH Values. 70.8% subclinical hypothyroid
subjects had LVDD. ECG changes suggestive of IHD and RWMA in 2D ECHO was
present in 48.3% and 37.1% of the subjects respectively.
Conclusion:In our study we found that subclinical hypothyroidsubjects have significant
elevation in MPV. It is also associated with left ventricular diastolic dysfunction. Hence
it is necessary to screen and treat high risk group for subclinical hypothyroidism and its
adverseoutcomes to minimize serious complications.