Online ISSN: 2515-8260

Keywords : Mean platelet Volume

Correlation of Mean Platelet Volume with Subclinical Hypothyroidism at Tertiary Care Hospital

M M Basavaraju, Sumaiya Anjum, Thejashwini A, Anoop Cheriyan

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 139-145

Background:Subclinical hypothyroidism (SH) is defined as elevated serum levels ofTSH
with normal levels of free T4 (fT4) and free T3 (fT3). The prevalence of SH has been
reported to be 4–10% in general population. Since it is generally asymptomatic, these
patients are mostly identified through routine screening or evaluation of non specific
symptoms. About 2–5% of patients progress to overt hypothyroidism annually.
Objectives: To study the mean platelet volume in patients with subclinical
hypothyroidism and to study the association between MPV and CAD in patients with
subclinical hypothyroidism.
Material &Methods:We studied 89 subclinical hypothyroid subjects and estimated
theirMean platelet volume and their cardiovascular function by ECG and 2D ECHO
and then analyzed the data.
Results:MPVwas high (>11fl) in 75.3% of subclinical hypothyroid and MPV has
significant positive correlation with TSH Values. 70.8% subclinical hypothyroid
subjects had LVDD. ECG changes suggestive of IHD and RWMA in 2D ECHO was
present in 48.3% and 37.1% of the subjects respectively.
Conclusion:In our study we found that subclinical hypothyroidsubjects have significant
elevation in MPV. It is also associated with left ventricular diastolic dysfunction. Hence
it is necessary to screen and treat high risk group for subclinical hypothyroidism and its
adverseoutcomes to minimize serious complications.



European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 766-771

Easily accessible, inexpensive, and widely used laboratory tests that demonstrate the severity of COVID-19 are important. Therefore, in this study, we aimed to investigate the relationship between mortality in COVID-19 and platelet count, Mean Platelet Volume (MPV), and platelet distribution width.
In total, 100 COVID-19 patients were included in this study. The patients were divided into two groups. Patients with room air oxygen saturation < 90% were considered as severe COVID-19, and patients with ≥90% were considered moderate COVID-19. Patient medical records and the electronic patient data monitoring system were examined retrospectively. Analyses were performed using the SPSS statistical software. A p-value <0.05 was considered significant.
The patients’ mean age was 64,32 ± 16,07 years. According to oxygen saturation, 38 patients had moderate and 62 had severe COVID-19. Our findings revealed that oxygen saturation at admission and the MPV difference between the first and third days of hospitalization were significant parameters in COVID-19 patients for predicting mortality. While mortality was 8.4 times higher in patients who had oxygen saturation under 90 % at hospital admission, 1 unit increase in MPV increased mortality 1.76 times.
In addition to the lung capacity of patients, the mean platelet volume may be used as an auxiliary test in predicting the mortality in COVID-19 patients.

Relation of Mean Platelet Volume with Diabetic Retinopathy in Diabetes Mellitus Type 2 Patients

Sushma S Biradar,Krupashree G, ,Mohammed Nizamuddin Attar , Manjunath Hiremani

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 10039-10048

Background: Diabetic retinopathy (DR) is one of micro vascular complications of Diabetes
mellitus and leading cause of blindness. Mean Platelet volume is a marker of average size and
activity of platelets. Larger platelets are younger and exhibit more activity and related to these
complications.Objective:to study the association between mean platelet volume and Type 2
Diabetes, and its correlation with diabetic retinopathy.Methods: In this study, 100 patients with
Type 2 diabetes and without retinopathy, 50 patients with type 2 diabetes and with diabetic
retinopathy and 50 healthy age and gender matched controls were chosen and evaluated
clinically and laboratory data including MPV, platelet count,HbA1C,Fasting and post prandial
blood glucose, lipid profile,creatinine levels were obtained and studied. All study was done by
SPSS software. Results: Mean MPV among subjects with DM with Retinopathy was 11.7 ± 1.3,
among subjects with DM without Retinopathy was 10.7 ± 0.9 and among normal controls was
8.8 ± 0.5. There was significant difference in MPV b/w 3 groups. In the study there was
significant positive correlation between MPV and duration of DM, FBS, PPBS and HbA1c i.e.
with increase in Duration of DM, FBS, PPBS and HbA1c there was increase in MPV and vice