Keywords : anti-B2GPI
To study the concentration of anti-B2GPI (IgG and IgMisotypes) in patients with collagen vascular diseases (auto-immune disorders), pregnancy related complication and thromboembolic disorders
European Journal of Molecular & Clinical Medicine,
2021, Volume 8, Issue 2, Pages 2762-2769
Background&Method: This is a retrospective study carried out with an aim to study the
concentration of anti-B2GPI (IgG and IgMisotypes) in patients with collagen vascular diseases
(auto-immune disorders), pregnancy related complication and thromboembolic disorders, in
patients who were tested for anti-B2GPI (IgG and IgM) and ACL (IgG and IgM) by the
standardized solid-phase enzyme linked immunosorbent assay (ELISA) in pathology department.
Result:The 38 patients with SLE presented with common clinical manifestations of SLE. In
addition, Raynaud’s phenomenon (n = 3) and photosensitivity (n = 4) were seen in a few.
Further, two each of patients with SLE had auto-immune hemolytic anemia, and history of
spontaneous abortions respectively. One of the two patients with spontaneous abortions had a
past history of a vertebrobasilar infarct. Renal involvement was noted in 13 (34.2%) cases, out of
which 11 had biopsy proven lupus nephritis, one case had mild mesangial proliferation and in
one ultrasound of the abdomen had shown medical renal disease. One patient had a clinical
diagnosis of deep vein thrombosis however results of radiological tests for confirmation if done
were not available. One other patient had pulmonary hypertension. The patient with primary
APS had presented with seizures and post-ictal confusion.
Conclusion:In present study ACL (IG & or IgM) was noted to be more prevalent than anti-
B2GPI (IG & or IgM) in patients with collagen vascular diseases (auto-immune diseases) and
thromboembolic disorders while they showed a similar prevalence in patients with recurrent fetal
losses. While we observed that there were certain differences in the prevalence of these
antibodies when compared to other published studies, this could be related to differences in