Online ISSN: 2515-8260

Keywords : Diabetic Macular Edema


Efficiency of Fenofibrate in Facilitating the Reduction of Central Macular Thickness in Diabetic Macular Edema

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 3160-3164

Background: Diabetic macular edema (DME) has been reported at rates of 10% and occurs more frequently in type 2 diabetes mellitus. The present study was conducted to assess the efficiency of fenofibrate in facilitating the reduction of central macular thickness in diabetic macular edema.
Materials & Methods: 60 patients with type 2 diabetes having treatment naïve, center‑involving DME of both genders were divided into 2 groups.  Group I had DME only in one eye and group II had DME in both eyes. Group I were given oral fenofibrate 160 mg/day for 6 months as a single evening dose. Central macular thickness in both groups was compared.
Results: The mean FBS was 137.6 mg/dl in group I and 158.2 mg/dl in group II, PPBS was 210.4 mg/dl and 238.6 mg/dl, blood urea (mg/dl) was 29.3 in group I and 31.5 in group II and serum creatinine (mg/dl) was 0.92 and 0.99 in group I and in group II respectively. CMT in group I and group II at baseline was 432.6 and 402.1, at 2 months was 360.2 and 358.1, at 4 months was 327.5 and 331.4 and at 6 months was 294.3 and 317.6 in group I and in group II respectively. The difference was non- significant (P>0.05).
Conclusion: Fenofibrate facilitate reduction of central macular thickness in patients with diabetic macular edema

Automatic detection of exudates for grading of macular edema in retinal fundus images

Dr. J.Benadict Raja; B. Sakthi Karthi Durai

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 4, Pages 1960-1968

Macular edema is one of the retinal variations from the norm which influence the vision of the individual and prompts visual deficiency torn up pretty bad. In this paper a completely robotized strategy is proposed for the early discovery of macular edema in retinal fundus pictures. At first, the anatomic structures of retinal picture, for example, vessel, optic disc and fovea are identified. At that point the exudates which are available in the fovea part are distinguished for reviewing macular edema. The proposed technique was assessed on the two openly accessible DRIVE and STARE databases.