Online ISSN: 2515-8260

Keywords : histopathological examination


A Clinical Study and Ultrasonography Diagnosis in Clinically Suspected Cases of Acute Appendicitis

Dr. Janardhan Jakkula, Dr. Ramesh Lingala, Dr. Shekhar Goud S, Dr. Sridhar Matta

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 4, Pages 1-11

Background: Acute appendicitis is the most prevalent cause of acute abdomen and
subsequent surgery. Misdiagnosis is a common and critical problem in general surgery
because the diagnosis is primarily based on clinical grounds. Maximum incidence observed
in the second and third decades of life, with male preponderance. Graded compression
ultrasonography is one of the diagnostic procedures that has been shown to reduce the need
for unfavourable surgical treatments, particularly in females.Objectives: Objectives of the
study were to study the clinical features of acute appendicitis, Utility of USG in supporting
the clinical diagnosis of acute appendicitis. Methods: This study included one hundred and
Twenty Five patients with history of RLQ pain where clinical diagnosis of acute appendicitis
was made. The study period was of 18 months between November 2019 to May 2021.
Routine bloodinvestigations and abdominal USG were done in all cases. All ultrasound
positive cases were subjected to surgery. Some ultrasound negative cases were also taken to
surgery on the high clinical suspicion of acute appendicitis. The ultrasound findings were
compared with clinical findings and histopathological examination reports.

CLINICAL STUDY OF SYMPTOMATOLOGY, MANAGEMENT AND OUTCOME IN PATIENTS WITH SINO-NASAL MASSES

Dr. Ratna Kumara Ambati, Dr.Bomma Vijay Kumar, Dr. Haritha Surasura, Dr.PolepeddiSarvaniPratyusha, Dr.PotlacheruvuNagaraju, Dr. DharmagaddaRanganath Swamy

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 4, Pages 921-927

Background: Presumptive diagnosis of sinonasal masses can be achieved with the aid of clinical presentation and imaging techniques but histopathological examination remains the mainstay of final definitive diagnosis. The present study was undertaken at a tertiary level hospital to analyse clinical presentations, management and histopathological patterns of Sinonasal masses.
Material and Methods: Present study was single-center, Prospective Non-Randomised study, conducted in patients of all age groups, attending the ENT OPD with masses in sinonasal cavity, diagnosed after complete clinical examination (including endoscopic evaluation), willing to participate.
Results: 40 cases presenting with Sino Nasal cavity masses at OPD were selected as per the inclusion criteria. In our study, most of the patients were in the age group of 31-40 years, with 25% of the study population, followed by patients in the second and third decade with 20% each. There were 24 (60%) males and 16 (40%) females in the study. Overall, non-neoplastic lesions were found to be commonest in occurrence with ethmoid polyp (32.5%) having the highest incidence, followed by antrochoanal polyps (20%), Rhinosporidiosis (2.5%) and Rhinoscleroma (2.5%). Among the benign masses, inverted papilloma was most common (12.5%) followed by hemangioma (10%), ossifying fibroma and osteoma (2.5% each). Carcinoma of the maxilla presented in 3 patients (7.5%) and was the most common malignancy followed by carcinoma of the nasal cavity (5%) and malignant melanoma (2.5%). For non-neoplastic lesions (n=23), majority of the masses were excised either by open surgery or endoscopically with base cauterization (n=21). One case of rhinoscleroma involved medical management along with surgical excision. Medical management was done with antibiotic ciprofloxacin for 6 weeks. Endoscopic surgery resulted in faster recovery and cosmesis.
Conclusion: Clinical diagnosis is often difficult and have to be relied on histopathological examination of biopsy specimen and may require repeated biopsies.

A Clinico pathological Study of Cystic Lung Lesions in Children and Prognostic Evaluation with Ki – 67 at Tertiary Care Hospital

Dr. Nadera Sultana, Dr. Sridevi P

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 659-663

Introduction: Congenital cystic lesions of the lung are uncommon but share similar
embryologic and clinical characteristics. An overall incidence of congenital cystic lesions
of the lung is 1/10,000 to 1/25,000 births (and 2.2% as compared to acquired lesions).
Presentation varies from life-threatening symptoms at birth to incidental findings at
autopsy. Diagnosis is either made in utero or due to complications of the lesion, such as
lung abscess, pneumonia, or pneumothorax.
Materials and Methods: This is a prospective study conducted in the Department of
Pathology at Ayaan Insitute of Medical Sciences, Kankamidi from January 2020 to
December 2021. The present study was done to evaluate the demographic profile,
clinical, radiological and histopathological findings of cystic lung lesions in children and
to demonstrate efficacy of Ki 67 as a prognostic marker in predicting malignancy in
these lesions. A total of 53 lobectomy specimens received and studied in the present
study.
Results: Out of these 53 cases were lobectomy specimens of cystic lung lesions. Highest
number of cystic lung lesions were observed in the left upper lobe. (23 cases) and the
lowest number of cystic lung lesions were observed in the right upper lobe (3cases).
Highest number of cystic lung lesions were Congenital lobar emphysema (52.83 %) and
least number of cystic lung lesions were Bronchogenic cyst (5.66 %). Among all cystic
lung lesions maximum cyst had size range between 0.5 to 2 cm. Immunohistochemical
staining using Ki 67 showed a high proliferative index in 5 cases of CCAM. Remaining
all 7 cases of CCAM and 2 cases each of Bronchogenic cyst, Intra lobar Sequestration
and Congenital lobar emphysema had low proliferative index.