Online ISSN: 2515-8260
Keywords : Neonatal Septicaemia
Clinical Profile of Neonatal Cholestasis in Neonatal Septicaemia
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 3, Pages 730-735
Background: Cholestasis is a known complication of gram-negative bacterial infection,
especially in infants. This syndrome is more frequent in the neonatal period and may
account for as much as a third of the cases of neonatal jaundice. Objectives: to
determine the prevalence of neonatal cholestasis in neonatal sepsis and to determine the
prevalence of Gram negative septicemia in neonatal sepsis.
Materials and Methods: This retrospective, observational study was conducted among
267 neonates attending in neonatal ward department of pediatrics at Dr. B.R.A.M.
Hospital, Raipur, Chhattisgarh.
Results: Only 47 infants out of 267 cases were having Cholestasis jaundice.
Overwhelming majority of infection in our study were caused by gram negative
organism Klebsiella pneumoniae (78.72%), E.coli (17.02%), Acinobacter (2.13%) and
S.aureus (2.1%). Association of Cholestasis with infecting organism in subjects with
neonatal sepsis was assessed using Chi square test. No significant association was found
to exist between two parameters (p=0.07).
Conclusion: It was concluded that majority of infection in our study were caused by
gram negative organism Klebsiella pneumonia, E.coli, Acinobacter and S.aureus.
Clinical Profile of Neonatal Cholestasis in Neonatal Septicaemia.
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 3, Pages 1154-1159
Background: Cholestasis is a known complication of gram-negative bacterial infection,
especially in infants. This syndrome is more frequent in the neonatal period and may
account for as much as a third of the cases of neonatal jaundice. Objectives: to
determine the prevalence of neonatal cholestasis in neonatal sepsis and to determine the
prevalence of Gram negative septicemia in neonatal sepsis.
Materials and Methods: This retrospective, observational study was conducted among
267 neonates attending in neonatal ward department of pediatrics at Dr. B.R.A.M.
Hospital, Raipur, Chhattisgarh.
Results: Only 47 infants out of 267 cases were having Cholestasis jaundice.
Overwhelming majority of infection in our study were caused by gram negative
organism Klebsiella pneumoniae (78.72%), E.coli (17.02%), Acinobacter (2.13%) and
S.aureus (2.1%). Association of Cholestasis with infecting organism in subjects with
neonatal sepsis was assessed using Chi square test. No significant association was found
to exist between two parameters (p=0.07).
Conclusion: It was concluded that majority of infection in our study were caused by
gram negative organism Klebsiella pneumonia, E.coli, Acinobacter and S.aureus.