Online ISSN: 2515-8260

Keywords : haemodynamic response


Dexmedetomidine 0.6 mcg/kg versus Magnesium Sulphate 50% 30 mg/kg for attenuation of Intubation Response

Velagalaburre Yalappa Srinivas, Mathikere Boregowda Sudarshan, Vivek Nayak, Kuzhippailil Vinod Kumar Harikrishnan, Narendra Babu Gowdagere Nagarajaiah

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 814-824

Background: Direct laryngoscopy followed by endotracheal intubation is prone to
haemodynamic fluctuations which may be detrimental in subjects with coronary artery
disease, hypertension, and cerebral vascular disease. The aim is we wanted to compare
Dexmedetomidine with Magnesium sulphate to determine the better drug with regard
to attenuation of the haemodynamic responses during laryngoscopy and endotracheal
intubation.

Efficacy of dexmedetomidine in attenuation of haemodynamic response to laryngoscopy and endotracheal intubation

Dr CH Nagaraju, Dr Gajagouni Nagaraj Goud, Dr Madanmohan Shiraboina, Dr Narugula Sadanandam

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 10267-10277

Background and Aims: Laryngoscopy and endotracheal intubation are associated with
strong sympathetic responsein the form of tachycardia and hypertension. The aim of
this study was to evaluate the efficacy of intravenous Dexmedetomidine in attenuation
of haemodynamic response to laryngoscopy and endotracheal intubation.
Materials and methods: In this prospective, randomized, double blinded study,A total
of hundred patients of ASA grade I and II between 18 to 50 years of age scheduled for
various elective surgical procedures under general anesthesiawere selected and
randomized into two groups of fifty patients each. Group C received 10 ml of normal
saline intravenously over 10 min, 10 minutes prior to induction. Group D received
injection Dexmedetomidine 0.5μg/kg body weight diluted to 10 ml normal saline
intravenously over 10 min, 10 minutes prior to induction. Baseline parameters like
Heart rate [HR], Systolic blood pressure [SBP], Diastolic blood pressure [DBP] and
Mean arterial pressure [MAP] were recorded in all patients before giving studydrug, 2
,5 and 8 minutes after studydrug, just beforeinduction, immediately after induction,
1,3,4,10 minute after laryngoscopy andintubation.
Results: There was no significant difference in the Age, Gender, body weight of patients
between Group C and Group D. After induction, In group D, there was no statistically
significant increase in the mean HR, SBP, DBP and MAP compared to basal value
whereas in group C, there was a statistically significant increase in mean HR, SBP, DBP
and MAP compared to basal value in group C.
Conclusion: In the present study, Dexmedetomidine at a dose of 0.5μ/kg body weight
given 10 minutes before induction significantly attenuated the haemodynamic responses
to laryngoscopy and tracheal intubation without significant side effects.