Online ISSN: 2515-8260

Keywords : MAP

Comparison between magnesium sulfate and dexmedetomidine in controlled hypotensionduring functional endoscopic sinus surgery

Dr.Sahaja Gunda, Dr.sravanthisuddapally, Dr. GiridharJanampetBekkam, Dr. PakalaSwathi

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 4, Pages 504-511

Background: Functional endoscopic sinus surgery (FESS) has been recommended as a
treatment option for chronic sinusitis patients who have failed to respond to medical
treatment. In order to maximize the visibility of the operative site during functional
endoscopic sinus surgery (FESS), it is critical to reduce bleeding. The goal of this study was
to examine the effectiveness of dexmedetomidine and magnesium sulphate as hypotensive
agents in FESS in adult patients in order to achieve a bloodless surgical field.
Materials and methods: Sixty patients aged between 18-65 years were randomly assigned into
two groups, the D group for dexmedetomidine (n = 30) the and M group for magnesium
sulfate (n = 30). Patients in the D group received a loading dose of 1 g/kg dexmedetomidine
in 100 mL saline solution 10 minutes before induction and a 0.5–1 g/kg/h infusion via syringe
pump throughout the surgery. Patients in the M group received 40 mg/kg magnesium sulfate
in 100 ml saline solution over 10 min as the intravenous loading dose 10 min before
induction,followed by a 10–15 mg/kg/h infusion.

Clinical Efficacy of Dexmedetomidine Versus Fentanyl Added to Intrathecal Levobupivacaine for Orthopedic Surgery

V. Sreelatha, Padmaja, Sudheer Kumar Gowd, Divya Manogna

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 892-913

Background: The present aim of the study is to compare the clinical efficacy of
dexmedetomidine versus fentanyl added to intrathecal levobupivacaine for orthopedic
surgeries on the lower limb.
Materials and Methods: The current study was a prospective randomized double-blind
comparative study. This study was done in 90 ASA grade I & II patients. The patients
were aged between 18 to 60 years scheduled for elective orthopedic surgeries under
spinal anaesthesia at Government General Hospital, Kurnool District, Andhra Pradesh.
The patients were distributed into three groups (30 patients each). Namely., Group-C
[Study group LN:15mg of 0.5% of Levobupivacaine + 0.5 ml of normal saline]-Total-
3.5ml, Group-D [Study group LD:15mg of 0.5% of Levobupivacaine + 5 mcg (0.05ml=2
units from insulin syringe) of dexmedetomidine+0.45 ml of normal saline]-Total-3.5ml
and, Group-F [Study group LF: 15 mg of 0.5% of Levobupivacaine + 25 mcg of
fentanyl]- Total =3.5 ml.

Comparison of changes in Heart rate and MAP between Intrathecal 0.75% ropivacaine with fentanyl and 0.5% bupivacaine with fentanyl for lower limb surgeries

Dr. Arjun Nair, Dr. Pramod Kohli, Dr. Rohit Balyan, Dr. Sachin Kumar, Dr. Maitree Pandey, Dr. Prashantha Kumar

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 2, Pages 2421-2426

Ropivacaine reversibly interferes with the entry of sodium into the nerve cell membranes, leading to decreased membrane permeability to sodium and raises the threshold for electrical excitability. It blocks the generation and the conduction of nerve impulses, presumably by increasing the threshold for electrical excitation in the nerve, by slowing the propagation of the nerve impulse, and by reducing the rate of rise of the action potential. Randomization was done using a random number table generated from computer software and divided into 2 groups of 40 each. Group B: 2.5 ml of 0.5% hyperbaric bupivacaine with 25 μg fentanyl, Group R: 2.5 ml of 0.75% isobaric ropivacaine with 25 μg fentanyl. The difference in the fall of heart rate from baseline in both the groups was clinically comparable. Only two (5% in group B) had an episode of bradycardia between 6-9 min after the sub-arachnoid block which resolved after a single dose of 0.6 mg of atropine in both the cases.