Online ISSN: 2515-8260

Keywords : ovarian tumors

Clinicopathological and Immunohistochemical Profile of Malignant Surface Epithelial Ovarian Tumors

Siji Mathew

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 946-952

Background: The ovaries are important organs for reproduction. The ovaries are
paired pelvic organs located on the sides of the uterus close to the lateral pelvic wall,
behind the broad ligament and anterior to the rectum. Generally ovarian tumors occur
in perimenopausal and post-menopausal women, infrequently in children also. The risk
of developing an ovarian malignancy peak in fifth decade of life. Aim and Objectives:
To Study and characterize the ovarian tumors based on gross and histopathological
features. To compare the frequency of benign and malignant neoplasms of the ovary
with other studies.
Materials and Methods: This study is a prospective study. The cases were obtained
from Department of Pathology, at a tertiary care hospital in Alappuzha over a period of
1 year. The gross specimen received were fixed in 10 % formalin for 24hours and from
every specimen multiple sections were taken from representative site for histological
examination. The number of blocks varied from four to eight in number. Sections were
processed in paraffin, which were cut at five microns thickness. Sections were stained
with conventional hematoxylin and eosin stain. The lesions were classified and studied
as per the WHO classification of ovarian tumors (2014).
Results: A total of 80 SEOT ovarian tumors were studied. Of these ovarian tumors, 42
were benign, 11 were borderline and 27 were malignant. Right sided tumors of ovary 48
(60%) were more common than the left sided tumors 25(31%). 07(09%) cases were
bilateral. The commonest epithelial tumors were serous 64 cases (75 %), 16 mucinous
(25%), remaining are not presented on my study period. Serous tumors formed the
majority of ovarian neoplasms in the study. There was a total of 64 serous tumors,
constituting about 75%.
Conclusion: The findings of this study indicate that IHC marker report of ER, PR
status and Ki-67 If included in each pathology report will pave the way for better
Understanding of Biological behavior and modify treatment strategies.

Study of Clinicopathological Examination of Ovarian Lesions in a Teaching Hospital

Manisha Jain, M. Sowbhagyalaxmi, BushraMaheena

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 1195-1205

Background: Ovary is the commonest site of physiological and pathological lesions
which can present in any age group and are common gynaecological problems
encountered by gynaecologists in their daily practice. Aim of the study: To study
Clinical, Radiological and Histopathological examination of ovarian lesions ina teaching
hospital .
Materials and Methods: Prospective observational study was done in the Departmentof
Obstetrics and Gynaecology, ShadanInstitute of Medical Sciences, Teaching hospital
and Research Centrefor duration of 01 year ie, from January 2021 to December 2021 on
100 ovarian specimens.
Results: Non neoplastic ovarian lesions constituted 84% and follicular cyst constituted
51.1%,next common was Corpus luteal cyst comprised 19%. Among 16 neoplastic cases
Surface epithelial tumours occupied 75%. Germ cell tumors constituted 18.7% and sex
cord stromal tumors constituted 6.2%.
Conclusion: Weanalyzed 100 ovarian lesions with respect to their clinical and
histopathological profile. Abdominal discomfort was the most common clinical
presentation. Benign tumours were more common than malignant ones across all age
groups. On histopathological examination, tumours originating from the surface
epithelium were the most common variant.

Assessment of gross and histological patterns of ovarian tumors

Pawan Kumar Saini, MD Shahbaz Alam, Piyush Kumar, Subhra Srivastava

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 5060-5064

Background:Ovarian tumors include a complex wide spectrum of neoplasm involving a
variety of histological diagnosis ranging from epithelial tissues, connective tissue,
specialized hormone secreting to germinal and embroyonal cells. The present study was
conducted to assess gross and histological patterns of ovarian tumors.
Materials & Methods:74 ovarian tumours were obtained in general pathology
department. Paraffin blocks were prepared, cut and stained with routine Hematoxylin
and Eosin stain. Special stains like reticulin, PAS etc., were used wherever required.
Results: Size<5 cm was seen among 28 and >5 cm in 46. Laterality was unilateral in 50
and bilateral in 24. Cystic/solid was unilocularcystin 30, multilocular cyst in 24 and
solid and cystic in 20. The difference was significant (P< 0.05). Germ cell tumors were
25, surface epithelial tumors in 44 and sex cord stromal tumors in 5 cases. The
difference was significant (P< 0.05). Serous tumours were benign seen in 18, malignant
in 8 and borderline in 4. Mucinous tumours were benign seen in 6, malignant in 4 and
borderlinein 4 cases. The difference was significant (P< 0.05).
Conclusion: Epithelial tumors are the commonest variety of ovarian tumors.