Online ISSN: 2515-8260

Keywords : Acanthosis nigricans


Dr.GontiPrakash,Dr. V.Siva Subramanian,Dr.C.Abhirami, Dr. Sowmya Machugari, Dr.T.Surya

European Journal of Molecular & Clinical Medicine, 2023, Volume 10, Issue 1, Pages 141-152

Background and objectives. Obesity is a major concern in our era with many adolescents and adults being obese.Obese patients with metabolic syndrome are more prone for cardiovascular risk. Obese individuals have numerous physiological changes which predispose them to many dermatological conditions. This is of concern to us as many of these conditions can act as markers for obesity and impending systemic consequences of obesity. This study was done to find the common dermatoses associated in adults with a BMI of > 30 kg/m2 who presented. Methodology All adult patients, of both sexes, who have a BMI > 30.0 and/or waist circumference > 90cm in males and > 80cm in females were included in the study.A detailed history of the patients was taken Morphology of skin lesions, sites of involvement, number of lesions were noted. A complete systemic and dermatological examination was carried out in all patients. ResultsThe age range of patients in this study was 18-85 years and the mean age was 40± 12.50. Acanthosis nigricans and skin tags had a strong correlation with obesityand Metabolicsyndrome. It was noted that in patients with acanthosis nigricans and skin tags, who were found to have metabolic syndrome, had elevated fasting plasma leptin levels but no elevation in fasting plasma Insulin levels.

Serum Insulin and Atherosclerotic Markers in Acanthosis Nigricans Patients

Shravya B, Navaneetha Reddy Pisati, Vijay Bhasker Reddy Ch, Chinnapu Reddy Gopu, Ashok Rao Matety

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 968-975

Background: To study serum insulin levels and atherosclerotic markers in patients with
acanthosis nigricans in a rural tertiary care center.
Materials and Methods: It was a Cross sectional study. The study was conducted in the
Departments of Biochemistry and Dermatology, Venereology, Leprosy (DVL), at
Kamineni Institute of Medical Sciences, India.
Results: Total number of patients recruited for the study was 50. Mean age of the
patient was 26.8 years. Females (60%) have outnumbered males (40%). Overall
majority of the acanthosis nigricans patients were students (46%). Among females
majority of them were housewives (22%). In a majority of the patients, neck was the
initial site of darkening (82%). Most of them have duration of darkening of skin for
more than one year (64%) and 84% of the patients had an insidious onset. Forty six
percent of patients had associated medical illness such as hypothyroidism (22%),
diabetes mellitus (10%), hypertension (8%), polycystic ovarian syndrome (4%),
psoriasis (2%). Neck(98%) is the most common site of acanthosis nigricans followed by
axilla(88%); elbow(42%); periorbital region(36%); groin(34%); knees(24%);
temples(22%); infralabial region(20%); antecubital fossa(14%); perioral and perinasal
(12% each); knuckles(10%); skin over hyoid bone(8%); sides of waist and
inframammary areas(6% each) and popliteal fossa(2%). Out of 50 patients, raised
serum insulin levels seen in 54% patients, of which 42% are non-diabetics and 12% are
diabetics. Also, 96% had normal fasting blood sugars (FBS <110mg/dL), 80% had
normal postprandial blood sugars (PPBS <140mg/dL). All patients (100%) had normal
total cholesterol (< 250mg/dL), 80% patients had normal HDLc (>35mg/dL), 98% had
normal LDLc (< 130mg/dL), 80% had normal triglycerides (<160mg/dL), 86% had
normal VLDLc < 40mg/dL, out of the total 50 patients with acanthosis nigricans.
Conclusion: Hypothyroidism was present in 22% of the patients with acanthosis
nigricans whereas diabetes mellitus was present in 10% of the patients with acanthosis
nigricans. Levels of fasting serum insulin were raised in 54% of patients having burke’s
neck severity score of 2, 3, 4 and neck texture score of 2,3 and axilla severity score of 2,3
in patients with acanthosis nigricans. About 20% of studied patients had decreased
HDL cholesterol levels(<35 mg/dL and increased serum triglycerides(>160 mg/dL).