Online ISSN: 2515-8260

Keywords : Propranolol hydrochloride


DEVELOPMENT AND CHARACTERIZATION OF CONTROLLED RELEASE TABLET BEARING ANTI HYPERTENSIVE DRUG

NIDHI SHARMA,PRANAV KUMAR UPADHYAY

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 1, Pages 623-636

Propranolol hydrochloride is used to treat high blood pressure, thyrotoxicosis, capillary
hemangiomas, performance anxiety, and essential tremors and used to prevent migraine
headaches. In this investigation-controlled release tablet of Propranolol Hcl was prepared
using different polymers such as xanthan gum, tragacanth, sodium carboxy-methylcellulose,
HPMC K4M, Eudragit S100, ethyl cellulose by direct compression method. All the precompression
and post compression parameters of designed formulations of F1-F8 were
evaluated and found to be within permissible limits. The optimized formulation (F7) showed
a maximum percentage of drug release (100%) within 6hrs when compared to other
formulations. From the FT-IR study it was concluded that there were no possible drug and
polymer interactions. The short-term stability studies were carried out at 40±2°C and 75±5%
RH and confirmed no changes in the weight, hardness and friability. Based on study results
it may be concluded that tablets prepared will emerge as eminent candidates in treatment of
hypertension.

FORMULATION DEVELOPMENT OF MODIFIED RELEASE DOSAGE FORM OF ANTIHYPERTENSIVE DRUG

Raosaheb S Shendge; Kishor S Salunkhe; Kashid Girish

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 4, Pages 2125-2133

Changed delivery dosage structures have been created to deliver drug to the aspect of the body where it will be ingested, to streamline dosing plans, and to guarantee that centralization of drug is kept up over a fitting time interval. Drugs that are not innately dependable require various every day dosing to accomplish the ideal therapeutic impacts. Numerous day by day dosing is regularly badly designed and can bring about missed doses, made-up doses and patient rebellious with therapeutic routine. Blood levels of drugs from conventional prompt delivery dosage structures taken more than once every day following distinct timetable normally demonstrate consecutive pinnacles and troughs (valleys) related with each dose. Intended to deliver their prescription in controlled way, at a pre-decided rate, span and area in the body to accomplish and keep up optimum therapeutic blood levels of drug.