Online ISSN: 2515-8260

Keywords : Ofloxacin


Assessment of fluoroquinolone resistance among pulmonary tuberculosis patients

Harish Chander Marwah

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 1624-1628

Background:Tuberculosis is most commonly found among people living in poor
conditions and in deprived areas, especially in elderly people and those with unstable
social or psychiatric backgrounds, such as hostel dwellers, street dwellers, alcoholics,
and drug misusers, as well as in immunocompromised patients.The present study was
conducted to assess fluoroquinolone resistance among pulmonary tuberculosis patients.
Materials & Methods:58 pulmonary TB patients of both genders were included. All
patients were subjected to DST for first-line drugs (FLDs) and second-line drugs. FQs
DST was also performed using automated Mycobacterial Growth Indicator Tube-960
liquid culture technique. The immunochromatographic assay was performed to
distinguish Mycobacterium tuberculosis complex (MTBC) from non-MTBC
Results: Out of 58, males were 38and females were 20. One drug resistance such as
Ofloxacin was seen in 28, levofloxacin in 3 cases, moxifloxacin in 1 and Kanamycin in 1
case. Two drug resistance such as Kanamycin+ Ofloxacin in 2 and Levofloxacin+
Ofloxacin in 1 case. Three drug resistance such as Ofloxacin+
Levofloxacin+Moxifloxacin in 1 and Ofloxacin+ Levofloxacin+ Kanamycin in 1 case and
all sensitive isolates was seen in Ofloxacin+ Levofloxacin+ Kanamycin+ Moxifloxacin in
20 cases. The difference was significant (P< 0.05).
Conclusion: Fluoroquinolone resistance among drug sensitive and multidrug resistance
tuberculosis isolates was high

Assessment of prescriptions for the treatment of typhoid fever in children

Harish Chander Marwah

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 1629-1632

Background: Typhoid fever is an acute systemic febrile illness caused by the bacterium
Salmonella enterica serovar Typhi. The present study was conducted to assess
prescriptions for the treatment of typhoid fever in children.
Materials & Methods: 110 patients of enteric fever of both genders were enrolled. A
thorough clinical examination was carried out. Clinical features and various antibiotics
used to treat these patients was recoded.
Results: Out of 110 patients, males were 60 and females were 50. Among culture
positive, 24 was IgM positive, 1 was widal positive and 23 were both IgM +ve, Widal
+ve. Among Culture negative, 28 were IgM positive, 10 were widal positive and 25 were
both IgM +ve, Widal +ve. The difference was significant (P< 0.05). Azithromycin was
used among 27, ofloxacin among 28 and cefixime among 55. The difference was
significant (P< 0.05).
Conclusion: Most common used antibiotics was cefiximefollowed by ofloxacin and
azithromycin.