European Journal of Molecular & Clinical Medicine

Background: There are various methods to diagnose different kinds of anaemia, but in developing countries many of the available investigation are also not feasible citing financial constraints. The present study was therefore conducted at tertiary care centre to assess RDW in different types of anemia; to investigate patients for peripheral smear picture, Iron Deficiency, Vitamin B12 Deficiency & Hemoglobinopathies wherever necessary; to determine efficacy of RDW in differentiating between Types of Anemia.
Methodology: The study was conducted as cross sectional study at Department of Medicine, PCMS and RC Bhopal during the study period of 18 months. A detailed history was obtained and examination was done. The study participates were then subjected to complete blood examination using hematology auto analyzer and RDW CV and RDW SD were recorded.
Results: This study included a total of 115 cases with anemia with mean age of 38.3±17.7 years. Mean RDW CV was lowest in hemolytic anemia, followed by anemia of chronic blood loss, dimorphic anemia and was highest in iron deficiency anemia (p<0.05). RDW SD was lowest in megaloblastic anemia, followed by anemia of chronic blood loss and hemolytic anemia (p<0.05). RDW CV as well as SD levels were significantly higher in severe anemia (p<0.05).
Conclusions: RDW is a simple and easily available screening tool helpful in screening of anemia as well as determining its severity. Red cell distribution width is increased in iron deficiency anemia and can be used routinely to differentiate iron deficiency anemia from other types of anemias with high accuracy. It can also be used in screening severe anemia irrespective of the type of anemia. RDW can be a cost effective tool for diagnosis of iron deficiency anemia as well as determining the severity of anemia

Red cell distribution width (RDW) have been found to be altered in uncontrolled diabetic patients because of consistent increase in HbA1c values that are known to induce functional and structural changes in Hb and an alteration in its cytoplasmic environment. Alteration in RDW may have a role in the diagnosis and monitoring of glycemic status along with its complications.
Objective: Present study aims towards analysis of correlation of red cell distribution width with HbA1c in T2DM patients.
Methodology: Present study was a case control study in which total 50 cases and 50 controls were recruited. Controls were the healthy non-diabetic patients and cases involved patients with diabetes. Patients were categorized as diabetic and non-diabetic as per American Diabetes Association Diagnostic Criteria. 3ml blood sample was obtained to analyze the RDW and HbA1c.
Results: The mean age of patients was 59.54±10.78 in the cases and was 55.40±15.63 in control group. The mean HbA1c was 10.79±2.45 was significantly high in cases compared to 5.59±0.31 in controls. The mean RDW was 13.69±1.31 in cases and 13.40±1.17 in controls which do not differ significantly. In diabetes patients, a non-significant positive correlation was observed between the HbA1c and RDW with the correlation coeffect of 0.027.
Conclusion: In present study, a non- significant correlation was observed between the RDW and HbA1c in diabetes patients. A multicentric study with a large sample size is required to establish diagnostic significance of RDW in diabetes patients.

Aim: The aim of the present study was to evaluate the role of utility of Red Blood Cell count, Red Cell Distribution Width, and Neutrophil/Lymphocyte Ratio as prognostic markers in type 2 Diabetes Mellitus patients with and without microvascular complications.
Methods: The present study is a cross-sectional analytical study. It was undertaken in the Department of Medicine of the parent institute Dr D.Y Patil Medical College, Hospital and Research Centre, Pimpri, Pune, during the period of October 2020 to September 2022 with the aim to evaluate the role of utility of Red Blood Cell count, Red Cell Distribution Width, and Neutrophil/Lymphocyte Ratio as prognostic markers in type 2 Diabetes Mellitus patients with and without microvascular complications.
A total of 300 patients were included in the study- 150 cases, with microvascular complications, and 150 controls, without microvascular complications.
Results: It was evident from the results that majority of patients were in the 51- 60 age group (29%) followed by 61-70years (25%) and 71-80years of age (20%).

Background: Red cell distribution width (RDW) to platelet ratio (RPR) is a
prognosticator in acute pancreatitis and myocardial infarction; however, the prognostic
values of RDW and RPR in breast cancer have not been studied. This retrospective
analysis of 50 breast cancer patients investigated the association between RDW and
RPR and clinicopathological characteristics and prognosis, compared to platelet
distribution width to platelet count ratio (PDW/P) which is a known independent
prognostic factor in patients with breast cancer. Aims and Objective: Our study aimed
to know significance of elevated RPR in breast cancer, to correlate the RPR with the
clinicopathological characteristics of breast cancer (tumor grade, lymphatic spread,
over expression of hormonal receptors and HER2 protein).
Materials &Methods:It was a Retrospective study. Patients with histologically
confirmed breast cancer were included in study. Patients with heart failure / On
dialysis/ Lacking the entire set of clinicopathological data were excluded in this study.
Results: RPR was higher in patients with breast cancer. RPR elevation was significantly
correlated with high grade tumors, number of infiltrated lymph nodes and HER2 over
expression.
Conclusion: Our study indicates that elevated preoperative RDW levels are indicative of
tumor spread and progression of breast cancer. RPR is a cost-effective and novel
biomarker which can help in assessing the microscopic grading of Breast cancer.