European Journal of Molecular & Clinical Medicine

Breast cancer is the most frequently diagnosed cancer as well as the leading cause of cancer death in women worldwide. As it is progressively affecting more women in productive age group, it is of utmost importance to help diagnose the disease at the earliest.
Aims: To find the accuracy of ultrasound in diagnosis of benign and malignant breast masses and to correlate the benign and malignant ultrasound features with tissue diagnosis.
Materials and Methods: The present study was a hospital based descriptive epidemiological study with cross sectional design. This Study was conducted from October 2021 - September 2022 at Department of Radiology, Murshidabad Medical College & Hospital. Total 94 patients were included in this study.
Result: Right breast was slightly more involved (44.7%) than left breast (40.4%) among the study participants. Upper outer quadrant of breast was commonest location for involvement (59.6%). FNAC suggests proportion of malignant breast lesion among 26.6% of the study participants.
Conclusion: Ultrasound was able to diagnose all the malignant cases missed by FNAC and in case of indeterminate reports by ultrasound FNAC was able to diagnose benign and malignant lesions accurately.

A palpable breast lump is defined as a dominant mass if it is 3-dimensional, distinct from surrounding tissues and asymmetrical relative to the other Breast. A method of definitive diagnosis of patients who present with palpable breast lump at the outpatient department is needed. It must be accurate, easy to perform affordable and acceptable to the patient. This study was conducted to correlation of the diagnostic accuracy of Fine Needle Aspiration Cytology (FNAC) in differentiating the benign and malignant lesions of palpable breast lump with histopathological correlation.
A Prospective descriptive study done in 50 patients presenting with palpable lump in the Breast to Surgery department, history taken, clinically examined and sent to Central Diagnostic Lab, cytopathology section for FNAC. Patient underwent Surgical procedure after correlating with clinical examination and radiological investigations. Post-operative specimen sent for Histopathological examination. Cytological diagnosis was compared with Histopathology. Specificity, sensitivity, accuracy, and predictive values were calculated using standard formulas. Diagnostic accuracy of FNAC was 94% and overall sensitivity of FNAC in diagnosing the palpable breast lump was 94%, specificity was 100%, positive predictive of 100% and negative predictive value of 93%. Study concludes that the diagnostic efficacy, sensitivity and specificity of FNAC were comparable to Histopathological examination. Hence FNAC becomes a very important diagnostic tool in palpable breast lumps as it shows a high degree of correlation with the final histopathology report.

Breast cancer affects women more than men. From puberty to death, breasts go through
constant physical and physiological changes related to menstruation, pregnancy, and
menopause. The goal was to classify different types of breast lesions and conduct a
clinicopathological study on them.Methodology: In the present study carried out at the
department of Pathology of ACSR Govt Medical College, Nellore AP during the period
from January 2019 to June 2021 (18 months) a total number of 150 FNAs were performed
on patients with breast lumps. Results: The youngest patient in this study was 12 years
and the oldest 79 years. Majority of the patients were in the age group of 21-40 years. In
majority of the patients i.e. From 150 aspirates, 65 were from the right breast and 70 from
the left. 15 cases involved both breasts.Upper outer quadrant of right and left breast had 39
and 35 cases of breast lumps, respectively. Lower outer quadrant of the right breast had 11
cases and upper medial had 11 cases. Two breast cases showed diffuse all-quadrant
involvement. 2 of the 45 cases were clinically suspected of malignancy and 1 of
fibroadenosis, but FNAC showed fibroadenoma. Three clinicocytologically discordant cases
lacked excision biopsy. 15 cases of breast cancer were in the right breast and 9 in the left.
Upper outer quadrant is most common for breast lumps. Side and quadrant distribution are
shown below. All 20 cases were confirmed by excision biopsy. FNAC diagnosed 18 IDC
NOS cases and 2 IDC Mucinous cases.CONCLUSION: FNAC is the procedure that is most
commonly used since it is an initial outpatient procedure that is straightforward, risk-free,
quick, and dependable. Additionally, it contributes to an early preoperative diagnosis of any
lump in the breast.

Background: World Health Organization reported that there were 14.1 million new
cancer cases, 8.2 million cancer deaths and 32.6 million people living with cancer within
5 years of diagnosis worldwide.
Materials and Methods: Data were collected on the bases of findings of history and
clinical examination. Fine needle aspiration cytology (FNAC) was done in patients with
palpable lump in breast and suspicious lesions. Suspected cases were sent for histo
pathological examination.
Results: Most of the cancer patients were found in the 51–55-year age group. In this
study, cyto-pathological features were occur, Fibroadenoma (54%), fibroadenosis(8%),
Fibrocystic disease(4%), seb. Cyst breast (2%), gynaecomastia(0%), breast
abscess(12%), mastitis(0%), ductal carcinoma(18%), paget disease of nipple(2%).
Conclusion: Benign breast lesions are more common among female population than
malignant lesion, the frequency of breast cancer is increasing rapidly across the global.

Background: World Health Organization reported that there were 14.1 million new
cancer cases, 8.2 million cancer deaths and 32.6 million people living with cancer within
5 years of diagnosis worldwide.
Materials and Methods: Data were collected on the bases of findings of history and
clinical examination. Fine needle aspiration cytology (FNAC) was done in patients with
palpable lump in breast and suspicious lesions. Suspected cases were sent for histo
pathological examination.
Results: Most of the cancer patients were found in the 51–55-year age group. In this
study, cyto-pathological features were occur, Fibroadenoma (54%), fibroadenosis(8%),
Fibrocystic disease(4%), seb. Cyst breast (2%), gynaecomastia(0%), breast
abscess(12%), mastitis(0%), ductal carcinoma(18%), paget disease of nipple(2%).
Conclusion: Benign breast lesions are more common among female population than
malignant lesion, the frequency of breast cancer is increasing rapidly across the global.