Online ISSN: 2515-8260

Keywords : PRP


Evaluation of clinico-radiological outcomes in patients with lumbar degenerative disc diseases treated with intradiscal PRP versus steroids: A prospective double blinded randomized controlled trial

Dr. Bhupinder Singh Brar, Dr. Vivek Jha, Dr. Guncha Kalia, Dr. Bhandari Vaibhav, Dr. Neelam Gupta, Dr. Mandeep Kaur Nanda, Dr. Monika Sharma

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 2, Pages 1079-1088

Context: To evaluate clinico-radiological outcomes in patients with lumbar degenerative disc
diseases treated with intradiscal PRP versus steroids.
Design: Prospective double blinded randomized controlled trial.
Aims: The aim of the study was to compare and assess radiological changes and clinical
outcome in patients with degenerative disc diseases when treated with intradiscal platelet rich
plasma and intradiscal steroid.
Objectives: To compare clinical outcome in PRP and steroid treated patients, to compare
radiological changes in PRP and steroid treated patients, to assess clinical outcome in PRP
and steroid treated patients at subsequent follow ups, to assess radiological changes in PRP
and steroid treated patients at subsequent follow up.
Settings and Design: Prospective double blinded randomized controlled trial.
Methods and Material: Adults (18-50 years) with chronic low back ache (> 6 months) nonradiating
who were unresponsive to conservative treatment. A total 40 patients were
randomized to receive intradiscal PRP (Group A) or steroid (Group B) after provocative
discography in the department of Orthopaedics in Maharishi Markandeshwar Medical
College and Hospital, Solan between the time period of November 2019 to September 2021
based on inclusion and exclusion criteria were enrolled for platelet rich plasma and steroid
infiltration in a randomized manner. Pain relief as assessed by change in VAS score,
functional assessment using change in Modified oswestry disability index (MODI). Pfirrman
and MSU grades as assessed by MRI.

A prospective study on the treatment of chronic non-healing ulcers using autologous platelet rich plasma

Neharika, Brajesh Pathak, Sanjiv Bhatia, Ravi Pratap Singh Rajey

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 9945-9953

Aim: To assess the effect of Platelet Rich Plasma (PRP) in non-healing ulcers.
Material and methods: It was a hospital based prospective cross-sectional &
observational study between July 2020 to June 2021, at Hind institute of medical
sciences, Safedabad, Barabanki. The history and examination were done bedside. In
cases where the condition of patients doesn’t warrant giving history, their relatives or
attendants were interviewed. A predesigned pretested semi-structured questionnaire
was filled by the interviewer. Data was entered in Microsoft Excel sheet. The study area
was General Surgery, Orthopaedics& medicine department, of Hind Institute of
Medical Sciences, Safedabad, Barabanki.Pus culture and sensitivity were sent then after
cleaning the wound with normal saline and betadine solution, already centrifuged
platelet rich plasma was injected subcutaneously inside, in the periphery of wound and
spread over floor of ulcer then dress with non-absorbent dressing. 1st dressing was
changed on the 3rd day of injection then dressing was changed on every 7th day.We
evaluated the effect of 1 dose of platelet rich plasma injection efficacy in wound/ulcer
healing & reduction in wound/ulcer size and follow-up by visual inspection.
Results: At admission, the mean wound area was 388.6±25.35 mm2 which was reduced
to15.54%at3rddayandthisreductionwasfoundtobestatisticallysignificant(p<0.001).
Furtherreductionwasobservedat 14th day (49.66%) and 21st day (64.40%) and these
reductions were statisticallysignificant (p value <0.001).At 21st day the % change in
volume was maximum for venous ulcer (69.25±4.43 %) and minimum for post
traumatic (65.27±9.11 %). No significant difference was found in % change in volume at
21st day among various ulcer types (p value =0.336).
Conclusion: Based on this study observation and result, we proposed that platelet rich
plasma is a safe bio-compatible, cost-effective, less time-consuming procedure and does
not require sophisticated equipment.

ASSESSMENT OF ROLE OF PRP IN MANAGEMENT OF OSTEOARTHRITIS OF THE KNEE

Dr. Sumit Pal Singh, Dr. Manmeet Singh , Dr. Shubham Pandoh, Dr. Anil Gupta, Dr. Nitish Sharma

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 2, Pages 2382-2386

Background: Osteoarthritis (OA) is a chronic, non-inflammatory rheumatologic disease which affects the synovial joints. The present study was conducted to assess the role of PRP in management of osteoarthritis of the knee.
Materials & Methods: 65 patients of osteoarthritis of the knee of both genders were enrolled.
Cartilage thicknesses were measured radiologically by ultrasound before and at third and sixth months after treatment. The severity of pain was evaluated by using VAS.
Results: Out of 65 patients, males were 30 and females were 35. Right side was involved in 34 cases and left in 31 cases. The mean VAS before treatment was 5.4, after 3 months it was 2.3 and after 6 months it was 0.8. The difference was significant (P< 0.05). The mean cartilage thickness before treatment was 0.5 mm, after 3 months was 0.7 mm and after 6 months it was 0.8 mm. The difference was significant (P< 0.05).
Conclusion: PRP is found to be effective in management of cases of osteoarthritis of the knee.