Online ISSN: 2515-8260

Keywords : GGT


A CROSS SECTIONAL ANALYTICAL STUDY TO EVALUATE THE PREVALENCE AND EARLY DIAGNOSIS OF NAFLD IN VARIOUS COMORBIDITIES USING LIPID PROFILE AND HEPATIC ENZYMES AS BIOMARKERS

Chiluka Kiran, Sanath Kumar, Bandi Suman

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 4, Pages 3058-3066

Background: Nonalcoholic fatty liver disease (NAFLD) is a global epidemic that is often asymptomatic and silent, and progresses slowly and is one of the most common causes of chronic liver disease. NAFLD affects a third of the world population with very much high prevalence among patients with diabetes mellitus, obesity, hypertension, dyslipidemia, hypothyroidism etc. The natural history of NAFLD ranges from pure steatosis to steatohepatitis (NASH) to cirrhosis and in some patientsto hepatocellular carcinoma (HCC). NAFLD has been found to be the hepatic components of metabolic syndrome which is one of the leading causes of chronic liver disease. This study aimed to determine the biochemical hepatic markers and lipid profile among NAFLD patients and their possible relationship with degrees of fatty liver and other comorbidities to aid the clinician tointervene early in order to delay the occurrence of complications associated with NAFLD.
Materials and Methods: In this analytical cross sectional study, 145 individuals aged 20–69 years referred to the Govt Medical College/ GGH Hospital Suryapet during the period from June 2021 to May 2022, were included through sequential sampling method after meeting inclusion and exclusion criteria and after taking informed consent and ethical committee approval. Serum lipid profile and Serum liver enzymes was estimated on ERBA EM 360 auto analyzer.
Results: We found significant increase in lipid parameters (TC, LDL-C, VLDL-C, and TG), liver enzymes (AST, ALT, and GGT) and decrease in HDL-C and AST/ALT (Deritis ratio) in NAFLD with type 2 DM compared to controls.
Conclusion: We conclude from our study that in obesity, dyslipidemia, hypertension, hypothyroidism and Type 2 DM the elevated liver enzymes and lipid profile could be biomarkers for the early diagnosis of NAFLD with Type 2 DM and other comorbidities.

An Observational Study of the Effect of Laparoscopic Cholecystectomy on Liver Function Test

Hari Om Dhaker, Shyam Bhutra, Yogendra Singh Chundawat, Naresh Kumar, Nani Dhaker, Saranshi Singh

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 2308-2314

Background: Cholecystectomy is a common treatment of symptomatic gallstones and other gallbladder conditions. As it gained worldwide popularity, it has become one of the most common operations performed in general surgical practice. In this study we aimed to investigate to determine changes in liver function tests after laparoscopic cholecystectomy.
Material & Methods: A prospective observational study done on 100 patients who underwent elective laparoscopic cholecystectomy were taken up for the study in the department of General surgery at JLN medical college and hospital, Ajmer, Rajasthan, India during period between January 2020 to December 2021. All patients who gave consent for the study underwent a standard clinical and laboratory evaluation including USG. Pre-operative investigations included liver function tests i.e. prothrombin time, bilirubin (total and direct), alanine transaminase, aspartate transaminase, alkaline phosphatase, total proteins, serum albumin, GGT, and LDH. The subjects under inclusion criteria have taken up for the study. The liver function tests have repeated 24 hours, 3rd day, 7th days, 10th days after the operation and compared.
Result: The mean age of the study population was 43.3 years with a standard deviation of 13.35 yrs. A negative t-STAT shows that the value of serum total protein, serum albumin was falling after the laparoscopic procedure. A statistically significant increase in the bilirubin(total and direct), SGOT, SGPT, GGT, LDH, and serum alkaline phosphatase levels were noted after laparoscopic cholecystectomy and no statistical significance in prothrombin time.
Conclusion: We concluded that statistically significant increase in the bilirubin (total and direct), SGOT, SGPT, GGT, LDH, and serum alkaline phosphatase levels after Laparoscopic cholecystectomy. There was a decrease in total protein and albumin and no change for prothrombin time. However, further studies with larger sample sizes and multi-center trials would yield more definite results, along with meta-analyses. We strongly suggest the consideration of confounding factors such ascomorbidities, duration of surgery, CO2 pressure, utilized anesthetic agents, and also longer period follow-ups.