Keywords : Thyroid profile
A Hospital Based Prospective Study to Evaluate the Lipid Profile in Patients Having Subclinical Hypothyroidism and Type-II Diabetes Mellitus
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 3, Pages 2324-2330
Background: Both Hypothyroidism and Diabetes alter lipid levels and are the leading causes of dyslipidemia in the current era. However, the pattern of altered lipid profile varies in the two diseases. Hence, the glycemic control in diabetics with Hypothyroidism (overt and subclinical) may not be good despite strict dietary and lifestyle modifications, and there are conflicting reports regarding this observation. The aim of this study to evaluated the lipid profile in patients having subclinical hypothyroidism and type-ii diabetes mellitus.
Materials& Methods: A hospital based prospective study done on 100 Patients aged above 40 years with a past history of type-2 Diabetes mellitus attending medicine OPD in government district hospital, Sirohi, Rajasthan, India during one year period. Lipid profile included Total cholesterol, LDL cholesterol, HDL cholesterol and plasma triglycerides. Fasting thyroid profile including plasma free T3, free T4, and plasma TSH were obtained using standard assays. The data collected were entered in the proforma and subjected to statistical analysis.
Results: Subclinical Hypothyroidism was present in 12% of cases.4% had overt hypothyroidism. Females were significantly higher in proportion than males among those who had subclinical hypothyroidism. The presence of subclinical hypothyroidism was not significantly related to higher levels of HbA1C. There was no significant effect on Total and LDL cholesterol, and HDL cholesterol, in patients with subclinical hypothyroidism.
Conclusion: We concluded that there is a significant increase in the incidence of subclinical hypothyroidism in patients with type 2 diabetes mellitus and this increase is associated with a significant rise in the triglyceride levels.