Online ISSN: 2515-8260

Keywords : FVC


Pulmonary Functions deteriorate with increasing duration of exposure to ionizing radiations

Dr. Gaurav Jain, Dr. Shefali Singhal, Dr. Tulika Singhal, Dr. Ashish Gupta .

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 2631-2636

Background – Radiologic technologists are under the exposure of ionizing radiations for long duration of their occupational work life. Ionizing radiations have previously been found to damage the lung tissue and cause fibrosis.
Methods–Spirometry, a measure of pulmonary function tests was performed on radiologic technologists (n=23) and was compared with healthy subjects (n=23). To assess the effect of duration of radiation exposure over spirometry, correlation analysis along with linear regression was performed with their duration of exposure to ionizing radiations.
Results – There was a significantly lower FVC % of predicted (p = 0.04) and MVV% of predicted (p =   0.05) values among radiologic technologists as compared to healthy controls.  Further with increasing duration of exposure to ionizing radiations, a significant negative correlation was observed for FVC % of predicted (p value = 0.004) FEV1 % of predicted (p value = 0.015) PEFR % of predicted (p value = 0.046) and MVV % of predicted (p value = 0.037).
Conclusion – Ionizing radiations affect the lungs of radiologic technologists and the restrictive type pattern was noted.  In subjects with higher duration of radiation exposure the effect is more pronounced.

Effect of Hemodialysis on pulmonary function in patients with End stage renal disease

Shailendra Mane, C Bhujbal, Rajashri Mane, Rajesh Khayalappa

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 9774-9782

Background: The intermittent hemodialysis (IHD) has been a useful renal replacement
therapy for critically ill patients.Pulmonary dysfunction in end-stage kidney disease has
been seen as a straight effect of circulating uremic toxins or a secondary effect of
volume overload, anemia, immune suppression, premature airway closure, ventilationperfusion
mismatching, severe mechanical loading, gas transfer defects, malnutrition,
electrolyte disorders, and/or acid/base imbalances.
Aim of the study: To study effect of Hemodialysis on pulmonary function in patients
with end stage renal disease.
Materials and methods: The present study was conducted at Department of Medicine,
D. Y. Patil Hospital, Kolhapur, Maharashtra.We sampled all the hemodialysis patients
from four selected units that met the inclusion and exclusion criteria.
Results: A prospective observational study was conducted at Department of Medicine,
D. Y. Patil hospital, Kolhapur. Total 103 study subjects were selected for study who
were undergoing regular hemodialysis in current institution. Male study subjects were
53 (51.46%) while females were 50 (48.54%). Among study subjects 103 subjects, 57
(55.34%) in stage IV followed by 46 (44.66%) were in stage V. Out of 103 subjects, 46
(44.66%) were doing hemodialysis since last 1 to 3 years followed by 41 (39.81%) of
subjects doing hemodialysis for previous 6 to 12 month. Conclusion: According to our
findings, it can be concluded that patients with ESRD who receive hemodialysis may
have a better pulmonary function after dialysis sessions, which is significant for FVC,
FEV1, FEV1/ FVC ratio and PEFR.