Keywords : histopathological
To study the histopathological spectrum of prostatic lesions and to classify them as benign, with associated inflammation, premalignant and malignant
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 3, Pages 2704-2712
Background: Gleason's system is now widely being utilized as the histologic grading system for prostatic cancer and is a powerful predictor of cancer behaviour.The present study was conducted to analyse the histopathological spectrum of prostatic lesions and to classify them as benign, with associated inflammation, premalignant and malignant.
Material and methods: The sample size was 302. Collected data was analyzed with descriptive statistics followed by chi- square test. Tests were used to analyze diagnosing benign and malignant prostatic lesions. p value was calculated and considered statistically significant when p value was less than 0.005.
Results: Out of 302 specimens, 72.5% were of BPH, 1% of PIN and 26.5% were of Adenocarcinoma. Majority (40.1%) of patients were in 7th decade (BPH) followed by in 8thdecade (33.4%) in adenocarcinoma. Of the total cases, majority of the specimens received were of TURP chips (74.8%). Most of the patients had grade II prostatomegaly on clinical examination in benign cases and grade IV in malignant cases. Out of 85 benign cases, majority (83 cases) had firm prostate. Of the 39 malignant cases, 33 prostates were hard and 6 were firm in consistency. Most of the patients (63.6%) in our study presented with acute and chronic urinary retention, increased frequency, poor urinary stream. Most common Gleason score in our study was 7(33.7% cases).
Conclusion: The present study concluded that out of 302 prostatic specimens studied, benign lesions were common, accounting for 72.5% and malignant lesions accounted for 26.5%.