Online ISSN: 2515-8260

Keywords : Neuropathy


SERUM 25(OH) VITAMIN D LEVEL AND ITS RELATION TO DIABETIC PERIPHERAL NEUROPATHY IN TYPE 2 DIABETIC PATIENTS

Ali Hanif Bhatti, Muhammad Faraz Shamshad, Dr Shiny Teja Kolli, Dr Praveen Kumar Komminni, Usman Ismail, Dr Amit Bhalla, Dr Immanuel Raju Tullimalli

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 6, Pages 40-44

Background: The present study was undertaken for evaluating serum vitamin D levels and its relation to diabetic peripheral neuropathy in type 2 diabetic patients.
Materials & methods: A total of 100 type 2 diabetic patients were enrolled in the present study. Complete demographic and clinical details of all the patients was obtained. Clinical examination was carried out in all the patients and data was recorded. assessment of peripheral neuropathy was done by neuropathy disability score (NDS) and nerve conduction studies. The NDS was established by bilateral examination of the pin–prick sensation, temperature sensation, vibration test, and Achilles tendon reflex. Serum levels were obtained and vitamin D levels were evaluated using auto-analyser. Correlation of vitamin D levels was done using auto-analyser. All the results were recorded and analysed using SPSS software.
Results: DPN was present in 56 percent of the patients. Mean vitamin D levels among the patients with and without DPN was 19.12 ng/ml and 32.95 ng/ml respectively. While analysing and comparing statistically, significant results were obtained.
Conclusion: Significant correlation exists between DPN and serum vitamin D levels among type 2 diabetic patients.

Pattern of GBS in Kashmir, a Northern Region in India

Irfan Yousuf wani, Zhahid Hassan, Tanveer Hassan baba, Summyia Farooq , Iqra Mehraj

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 6, Pages 1218-1225

Background: Guillain-Barré syndrome (GBS) is said to be most common cause of acute flaccid paralysis worldwide. It is also one of the important life-threatening emergencies requiring critical cares in neurology. There are many subtypes of GBS like acute inflammatory demyelinating polyradiculoneuropathy (AIDP), acute motor axonopathy (AMAN) and acute motor sensoryaxonopathy (AMSAN).  GBS shows a lot of variation in the demographic variables like gender distribution and seasonal variation as seen in different studies. The frequency of different variants of GBS is also quite variable. AIDP is more common in Europe and North America whereas axonal subtypes are more often seen in Asia and South America. We conducted this study over a period of Two years to determine these features of GBS in our population.
Material and Methods:92 patients comprising of 49 male and 43 female patients were included in this study. All these patients were admitted in our hospital and were evaluated as per the established protocol. Baseline investigations were done in all the patients. Neurophysiology and CSF analysis was also done.
Results: In our study we found that most of the patients had AIDP. A preceding precipitating event was present in 31 patients. There was a significant seasonal variation in our population with majority of the cases occurring in spring season.  We also found that there were a significant number of patients who presented to us in postpartum period.
Conclusion: This study shows that knowing the demographic variations of GBS patients of a region is important so as to prepare the healthcare facilities for better management of such cases.

The associated risk factors and the prevalence of diabetic foot ulcer - A cross sectional study

Dr.UroojNajami, Dr. Faisal Mumtaz, Dr.PrabodhBansal, Dr Gopal

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 2824-2830

Background: Diabetes Mellitus is a worldwide epidemic, affecting over 346 million people globally, with India ranking second with 65.1 million diabetic patients. Foot ulceration is the most common consequence of diabetes mellitus.It affects about 15% of diabetic individuals over the course of their lives and is quite frequent.To a considerable extent, it is preventable if the risk factors are identified early. The aim of present study is to evaluate the association of risk factorswith diabetic foot ulcer and to estimate prevalence of diabetic foot ulcer (DFU).
Material and Methods: A systematic random sample of 500 diabetic patients was selected from patients attending the outpatient department of General Surgery, National Capital Region Institute of Medical Sciences, Meerut. A standardized form was used to record data obtained from reviewing the medical records, interviewing, and examining the patients.
Results:The sample had a male-to-female ratio of 48 percent. The average age of the participants was 55 years, and they had diabetes for an average of 8.9 years. The prevalence of diabetic foot ulcers was 4.8%, sensory neuropathy was 15.3%, lower limb ischemia was 8.2%,and amputation was 2%. Ulceration was linked to male gender, neuropathy, and having diabetes for a longer period of time.
Conclusion:Future efforts should focus on educating both healthcare professionals and patients about proper foot care. To ascertain the true prevalence of diabetic foot problems, community-based research is also required.