Online ISSN: 2515-8260

Keywords : Thyroid hormone


INVESTIGATING THYROID DYSFUNCTION IN CASES OF ABNORMAL UTERINE BLEEDING AMONG GESTATIONAL PATIENTS

Prof. (Dr.) Seeba Hussain

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 4, Pages 2964-2971

Introduction: A prevalent diagnosis with significant social and economic consequences, abnormal uterine bleeding (AUB) accounts for 20–30% of patients in the outpatient clinic. Heavy menstrual bleeding complaints have a large negative impact on quality of life, necessitate time away from work, necessitate surgical intervention, including hysterectomy, and eventually have a significant negative impact on the health care system. The majority of these issues can be avoided with prompt and effective management.
Methods: A ten month cross-sectional prospective study on 100 women (50 with abnormal uterine bleeding and 50 with a regular cycle were chosen as control cases) was carried out in the outpatient department at Katihar Medical College and Hospital. Both study groups had their general and menstrual histories, examinations, and thyroid function tests evaluated.
Results: Women who experienced abnormal uterine bleeding were significantly more likely to have high thyroid stimulating hormone levels (p=0.002). Low T4 levels were strongly related with women who experienced abnormal uterine bleeding (p=0.04). Women with abnormal uterine haemorrhage and hypothyroidism were shown to be significantly associated (p=0.003).
Conclusion: Maintaining a high index of suspicion and quickly screening for the existence of abnormal thyroid function are crucial for making an early diagnosis.

STUDY OF THYROID DYSFUNCTION AMONG METABOLIC SYNDROME PATIENTS IN RURAL POPULATION OF CENTRAL INDIA

Kamal Kachhawa, Vivek Jain, Kapil Dev Arya, Poonam Kachhawa, Prashant Harit, M Prasanna Chandra

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 2895-2905

Background: Thyroid dysfunction with metabolic syndrome is recognized risk of atherosclerotic and cardiovascular disease. This study is an effort to investigate the proposed association between these two disease entities and to identify the factors that increase the risk of this association. Methods: A cross sectional study from a teaching hospital in Bhopal city of central India. Total80 patients with metabolic syndrome were included in this study. Metabolic syndrome patients required to fulfil NCEP-ATP III criteria and 80 patients without metabolic syndrome were allocated into the control group. The biochemical parameters like: Fasting Glucose, Lipid Profile, Thyroid Profile, Hs-CRP, FINS, HOMA-IR levels were determined for assessment of metabolic dysfunctions. Results:Fasting blood sugar, Total cholesterol, LDL and TAG level of metabolic syndrome subjects are significantly increases compare than to control group. Abnormal thyroid functions were found in metabolic syndrome group compare to control group. Hs-CRP, FINS and HOMAIR level of metabolic syndrome subjects are significantly increases compare than to control group. Conclusion: Our study suggests that a slight increase in serum TSH might be a risk factor for metabolic syndrome. Therefore, the screening of thyroid level essential to reduce the severity of disease and further investigations are needed to evaluate the mechanism of this correlation.