Online ISSN: 2515-8260

Keywords : double-blind study


A Study on C-Reactive Protein as a Diagnostic Parameter in Acute Appendicitis

Naveen Banoth, Venkatesh A .

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 3131-3137

Background: Even though appendicectomy is the most regularly performed emergency surgery, its diagnosis remains uncertain, with a high probability of negative investigations. The study's goal was to investigate the relevance of CRP measurement accuracy in the diagnosis of acute appendicitis and to reduce morbidity by avoiding negative exploration.
Materials and Methods: The present investigation included 30 patients who were clinically diagnosed by surgeons as having acute appendicitis and were sent for an emergency appendectomy at the General Surgery Department, JSS Hospital Mysuru, between the 1st of December 2020 and the 1st of May 2021. Preoperative blood was sent for CRP estimation; postoperative, all specimens were sent for histopathological evaluation; CRP values were correlated with HPE reports to evaluate their function in the diagnosis of acute appendicitis.
Results: In the current study, CRP had the highest sensitivity and specificity of 90% and 80%, respectively, with a positive predictive value of 90%. As a result, it was demonstrated that CRP levels can be used to rule out negative appendicitis, allowing surgery to be postponed in these patients and lowering the rate of negative appendicectomies.
Conclusion: We continue to highlight the importance of a professional surgeon's history and clinical examination in detecting acute appendicitis. CRP, on the other hand, significantly reduces the rate of negative appendicectomy and, as such, should always be included in the diagnostic workup of acute appendicitis