Online ISSN: 2515-8260

Keywords : vecuronium

A Prospective Randomized Comparative Study of Hemodynamic Effects of Etomidate vs Propofol During Induction and Intubation Under General Anaesthesia

Sarpatwar Sailesh, Boini Chiranjeevi

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 4749-4756

Background:The aim of the study is to compare induction with etomidate and propofol
on hemodynamic response to laryngoscopy and intubation.
Materials and Methods: The study was conducted in 60 ASA I & II patients in the age
group of 18 to 60 years who were posted for elective surgeries under general
anaesthesia. Their baseline heart rate, systolic blood pressure, diastolic blood pressure,
SpO2 and ETCO2 were recorded. Both the groups were premedicated with iv
glycopyrrolate 5mcg/kg, iv midazolam 0.025mg/Kg, iv fentanyl 2mcg/Kg. Following
premedication, the above variables were again recorded. Group P patients were
induced with iv propofol at the dose of 2 mg/Kg and Group E patients received iv
etomidate at 0.4mg/Kg. In both the groups, Injection vecuronium was given at the dose
0.08mg/Kg and they were maintained with O2:N2O =33%:66% and Isoflurane 1% dial
concentration. Laryngoscopy was performed by trained anesthesiologists after 5 mins.
Duration of laryngoscopy was kept at a maximum of 10 seconds. Trachea was intubated
with appropriate size endotracheal tube. The variables (HR, SBP, DBP, MAP, SpO2)
were measured during induction, intubation and post intubation at intervals of 1,2,3,5
and 10 mins.
Results: On comparing the two groups, the following results were obtained – Age, Sex,
Weight and ASA status were comparable in both the groups. Propofol was found to
produce hypotension in more or less 20%- 30% of patients irrespective of the
underlying condition. Etomidate was found to maintain hemodynamic stability though
there were no significant difference in heart rate variability in both the groups during
laryngoscopy and intubation. Myoclonus was seen in 4 out of 30 patients induced with
Etomidate, pain on injection was more common with Propofol. Apnea occurred in 12
out of 30 patients induced with Etomidate,28 patients out of 30 in propofol group,
vomiting and nausea are more with Etomidate than propofol but the difference was
statistically insignificant.
Conclusion: As per the results of the study, Propofol produced more hemodynamic
changes than Etomidate. Thus, we conclude that Etomidate is more stable in terms of
hemodynamic stability.

Comparative study of intubating condition and duration of action after administration of rocuronium bromide and vecuronium bromide in abdominal surgery using train of four

Dr. Arata Kumar Swain, Dr. Suryasnata Sahoo, Dr. Harekrushna Dalei, Dr. Basanta Kumar Pradhan

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 2, Pages 1909-1914

Background: Rocuronium Bromide, an intermediate acting amino steroid NMDR, is five to seven times less potent than Vecuronium used in this study was to compare time of onset, conditions of tracheal intubation, duration of action and hemodynamic parametres, either of the drugs are used to produce muscular paralysis.
Materials & Methods: Study was carried out by taking 60 adult patients, undergoing different elective abdominal surgery under general anaesthesia, in age group of 15-60 years with ASA physical status I or II,30 patients received 0.6 mg/kg of Rocuronium bromide as Intubating dose and the other 30 patients received 0.1 mg/kg of Vecuronium bromide. Then neuromuscular blockade, endotracheal intubation of two non-depolarizing muscle relaxants were evaluated using a TOF in adductor pollicis muscles.
Results: In both the groups intubating conditions were either excellent or good. Intubating conditions with Rocuronium group were excellent in 86.67% and good in 13.33% patients while in Vecuronium group, intubating condition were excellent in 80% and good in 20% patients, which were comparable and statistically not significant (p=0.488). The onset of action of Rocuronium was found to be rapid compared to Vecuronium group with high statistical significance. (p=0.000).