Online ISSN: 2515-8260

Keywords : Thyroid dysfunction


To Study Association Of Thyroid Dysfunction With Diabetes Mellitus In Antenatal Women

Dr. Parul Sharma, Dr. Kamakshi Mam, Dr. Mehak Khazanchi, Dr. Vanshika Gupta, Dr. Saagar Anand, Dr. Amita Gupta, Dr. Gokul Sharma .

European Journal of Molecular & Clinical Medicine, 2023, Volume 10, Issue 1, Pages 2606-2611

Introduction: The two most prevalent endocrine conditions that can be seen during pregnancy are thyroid dysfunction and gestational diabetes (GDM). Changes in glucose metabolism and insulin resistance (IR) can both be linked to abnormalities in thyroid function. The study's objective was to ascertain whether pregnant women with gestational diabetes have aberrant thyroid hormone levels.
Material and methods: The medical files of 662 pregnant women who gave birth between 2020 and 2022, separated into two groups: 412 with GDM and 250 with normal glucose tolerance. Using the International Federation of Gynecology and Obstetrics (FIGO) and American Diabetes Association (ADA) standards, a 2-h, 75-g oral glucose tolerance test (OGTT) was used to determine the presence of gestational diabetes mellitus in the study group. TSH, free thyroxine, free triiodothyronine, the FT3:FT4 ratio, fasting plasma glucose, age, and body mass index were all examined in both groups' mean blood concentrations. The Mann-Whitney U-test was used to compare the two groups.
Results: Significantly greater TSH and FT3 concentrations (p 0.0001), lower FT4 concentrations (p 0.0001), and higher FT3:FT4 ratios (p 0.0001) were reported in patients who acquired GDM.
Conclusion: According to the findings of this pilot retrospective series, high-normal to high TSH levels, low-normal to low FT4 levels, and a high FT3:Ft4 ratio may all point to an increased risk of developing GDM.

A CLINICAL STUDY OF CIRRHOSIS WITH SPECIAL REFERENCE TO THYROID FUNCTION”

Dr. M.H. Usmani, Dr. Karan Saran Kapur, Dr. Sabendra Singh Sikarwar, Dr Anuj Jain

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 7, Pages 151-161

Background-It is known that impaired thyroid function affect the liver function and similarly liver disorders Also affect thyroid function. In this study we looked  at the clinical profile of cirrohosis and studied the correlation between cirrhosis  and thyroid function.
Methodology- The study was conducted as an observational cross sectional Study on patients with cirrhosis of liver reporting at Department of Medicine, SSMC Rewa (M.P.) during the study period of 15 months i.e. from 1st April 2020 to 30th June 2021. Detailed history regarding risk factors, duration of liver disease, history pertaining to its etiology was obtained. Severity of liver disease was assessed using Child Pugh score. All the patients were then subjected to relevant investigations including Serum T3, T4, TSH.
Results-A total of 100 cases of liver cirrhosis were enrolled in our study with mean age of 53.26±12.54 years. We observed a statistically significant association of Child Pugh Score with T3, T4 as well as TSH (p<0.05). We observed a moderate correlation of Child Pugh score with T3 levels and TSH (r=0.452 and
0.311 respectively; p<0.05), and weak correlation was observed with T4 (r=0.240; p<0.05).
Conclusion- In cirrhosis of liver majority of subjects show impaired thyroid functions. Thyroid hormone levels are helpful in assessing the severity as well as course of cirrhosis and among T3,T4,TSH value,TotalT3 faired as better predictor of severity of cirrhosis.

A STUDY OF THYROID FUNCTION TEST IN PATIENTS WITH DIABETES MELLITUS

DR.PARTH R. JANI,DR. PANKAJ. J. AKHOLKAR,DR. SAGAR S. GARCHAR, DR. N N. PANDYA

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 4, Pages 491-503

Introduction:  
Diabetes mellitus (DM) is a growing problem in our country and we have observed that many patients are associated with thyroid dysfunction later in their life. Hence, the prevalence of thyroid dysfunction in diabetes mellitus patients should be evaluated. 
Objectives:  
To evaluate spectrum of thyroid disorders in diabetic patients and To access  altered thyroid function in patients with diabetes mellitus regarding age, sex, duration of  diabetes, family history, regularity of treatment and BMI.  
Materials and Methods:  
In this cross sectional study, after taking permission from ethical committee, data of 280 DM patients who attended the OPD clinic of sir  takhtasinhji hospital, Bhavnagar over period of 9 month, and whose thyroid stimulating  hormone (TSH), free T3, free T4 level were investigated, were included. The inclusion criteria were known cases of DM. Exclusion criteria were patients with previous history of thyroid disorder and those on drugs affecting the thyroid profile, chronic renal failure and Diabetic nephropathy, acute illness, hepatic dysfunction, psychiatric illness, Pregnancy.  
 
Results:  
Out of 280 DM patients 158 were males and 122 were females, 195 (69.64%) were euthyroid, 37 (13.22%) had subclinical hypothyroidism, 23 (8.21%) had overt hypothyroidism, 14 (5%) had subclinical hyperthyroidism and 11 (3.9%) were overt hyperthyroidism cases.  Female sex (P < 0.0091) and patient with irregular treatment (P < 0.001) were at increased risk of having hypothyroidism.  
Conclusion:  
 
Prevalence of thyroid dysfunction was high in DM patients with female sex and patients with irregular treatment.  
Introduction:  
Diabetes mellitus (DM) is a growing problem in our country and we have observed that many patients are associated with thyroid dysfunction later in their life. Hence, the prevalence of thyroid dysfunction in diabetes mellitus patients should be evaluated. 
 
 
 
Objectives:  
To evaluate spectrum of thyroid disorders in diabetic patients and To access  altered thyroid function in patients with diabetes mellitus regarding age, sex, duration of  diabetes, family history, regularity of treatment and BMI.  
 
Materials and Methods:  
In this cross sectional study, after taking permission from ethical committee, data of 280 DM patients who attended the OPD clinic of sir  takhtasinhji hospital, Bhavnagar over period of 9 month, and whose thyroid stimulating  hormone (TSH), free T3, free T4 level were investigated, were included. The inclusion criteria were known cases of DM. Exclusion criteria were patients with previous history of thyroid disorder and those on drugs affecting the thyroid profile, chronic renal failure and Diabetic nephropathy, acute illness, hepatic dysfunction, psychiatric illness, Pregnancy.  
 
Results:  
Out of 280 DM patients 158 were males and 122 were females, 195 (69.64%) were euthyroid, 37 (13.22%) had subclinical hypothyroidism, 23 (8.21%) had overt hypothyroidism, 14 (5%) had subclinical hyperthyroidism and 11 (3.9%) were overt hyperthyroidism cases.  Female sex (P < 0.0091) and patient with irregular treatment (P < 0.001) were at increased risk of having hypothyroidism.  
 
Conclusion:  
Prevalence of thyroid dysfunction was high in DM patients with female sex and patients with irregular treatment.  
 

LOW SERUM FREE TRI-IODOTHYRONINE HORMONE AS A POSSIBLE PROGNOSTIC FACTOR IN ALCOHOL RELATED LIVER DISEASE

Dr Leelaraghavan G R, Dr Gnanendra D M,Dr sheshanv.s,Dr Kiran S,Dr Abhiman Shetty B,Dr R Madhumathi

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 5004-5009

Introduction: The levels of thyroid hormone & thyroid binding proteins are altered in patients of
chronic liver disease. Our aim was to assess the serum freeT3 and serum free T4 levels, in alcohol
related liver disease and to find the correlation between thyroid hormone levels and severity of
alcohol related liver disease.
Methods: A cross sectional study, with a sample size of 50, was done to assess the serum free T3
andserum free T4 levels of thyroid function andto correlate them with prognostic factors of alcohol
related liver disease, i.e.MELD-Na - which is derived by adding serum sodium to the original Model
for End-Stage Liver Disease (MELD) score and Maddrey’sDiscriminant Function (DF).Statistical
analysis was done with - Chi-Square test, p value <0.001 was considered as statistically significant.
Results: Of the 50 patients, low serum free T3 levels were found in 29 patients, among them15
patients had DF<32; 14 patients had DF>32(p value <0.001), and 14 patients had MELD-Na<24.50;
15 patients had MELD-Na >24.50(p value <0.006). Low serum freeT4 levels were found in 12
patients, among them 4 patients had DF<32;8 patients had DF >32 (p value <0.001), and 8 patients
had MELD <24.50; 4 patients had MELD >24.50(p value <0.825).
Conclusion: Significant decrease in the serum free T3 levels was found in patients of alcohol related
liver disease with Maddrey’sDiscriminant Function >32 and MELD-Na >24.50 (both prognostic
markers of more severe liver disease). Hence, low serum free T3 level can be used as a prognostic
indicator of severity of alcohol related liver disease.