Keywords : MDR
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 3, Pages 5082-5090
Aim: In light of the paucity of data on the bacteriological layout of AECOPD sufferer in
our country, the current study examined the layout of sputum bacteria and antibiotic
sensitivity in AECOPD hospitalized patients.
Material and methods: It was a prospective observational study conducted among 45
AECOPD patients diagnosed according to GOLD guideline (2019) in the department of
pulmonary medicine, TMMC & RC, Moradabad. Sputum sample was collected in the
morning before any meal & patient should not use oral antiseptics. After inoculating the
sample for 48 hours, inoculation culture plate with growth was identified on the basis of
culture characteristics, gram staining and biochemical reaction according to standard
guidelines.The antibiotic sensitivity of recovered isolates were determined by Kirby
Bauer disc diffusion method.
Results: The findings revealed that pseudomonas aeruginosa (42.2%) was the most
common isolated organism.It was sensitive to Cefepime (except one case),
Cefoperazone+Sulbactum, Ceftazidime (except one case), Meropenam (except two
cases), Colistin and Piperacillin+Tazobactum but resistant to Tigecycline and
Levofloxacin.Enterococcus species were sensitive and resistant to Linezolid and
Levofloxacin respectively. All the Escherichia coli cases were sensitive to Cefepime,
Cefoperazone+Sulbactum (except one case), Meropenam, Tigecycline, Colistin,
Piperacillin+Tazobactum but resistant to Ceftazidime and Levofloxacin.
Staphylococcus aureus were resistant to Levofloxacin and Linezolid.Staphylococcus
aureus (MRSA) was resistant to Levofloxacin and sensitive to Linezolid, Clindamycin
Conclusion:Antibiotics must be prescribed depending on the bacterium susceptibility
profile found in the area. Prescribed patients with history for production of purulent
sputum is worth following the guidelines or protocol. It is high time to have a policy for
antibiotics usage at different levels- district, state and country to prevent the emergence
of MDR strains.