Online ISSN: 2515-8260

Keywords : Light Criteria


To assess the diagnostic role of pleural fluid cholesterol in categorizing type of pleural effusion

Dr. DevashishVerma, Dr. MazherMaqusood, Dr. PradeepNirala, Dr Abhishek Kumar, Dr SanchitPeriwal

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 5099-5106

Aim: The present study was conducted to assess the diagnostic role of pleural fluid
cholesterol in categorizing type of pleural effusion.
Material and methods: The present prospective observational study was conducted on
51 patients hospitalized to the Department of Pulmonary Medicine, TMMC & RC,
TMU, Moradabad, for a period of one and a half years. Patients with definite clinical
diagnosis and pleural effusion evidenced by radiological imaging and thoracentesis
yields a sufficient good quantity of pleural fluid for examination was included in the
study. Pleural fluid cholesterol was investigated and compared according to Light’s
criteria.
Results: Maximum subjects were suffering from moderate amount of pleural effusion.
Exudative pleural effusion was found in 94.1%, 86.3%, 72.5% of the subjects while
transudative pleural effusion was found in 5.9%, 13.7%, 27.5% of the subjects
according to Light’s criteria, cholesterol at cut off 45 and 60 respectively. The mean
pleural fluid cholesterol level in the exudates and transudates was 85.11±34.13 and
31±7.21 mg/dl with statistically significant difference as p=0.009. Cholesterol at cut of 45
was found to be better predictor of exudative and transudative pleural effusion
considering Light's criteria as gold standard.
Conclusion: Cholesterol effusion has the advantage of avoiding plasma protein, sLDH,
pleural fluid protein, and LDH. Cholesterol at 45 was the best cut for detecting pleural
effusion. As a result, distinguishing exudates from transudates is more efficient, easier,
and cost-effective.