Online ISSN: 2515-8260

Keywords : Hepatic

Serum albumin gradient and total protein in ascitic fluid of hospitalised patients with hepatic and non-hepatic ascites compared

Dr. Krishna Tej Chikyala

European Journal of Molecular & Clinical Medicine, 2023, Volume 10, Issue 2, Pages 1251-1257

Analysis of ascitic fluid is useful for diagnosing ascites, one of the most prevalent issues a doctor faces in practice. Traditionally, ascites has been divided into two types exudative and transudative based on an estimate of the AFTP.
Methods: 50 patients admitted to the medical ward of the General Medicine, Kamineni Academy of Medical Sciences and Research Centre, Hyderabad, participated in a study comparing the serum ascitic fluid albumin gradient with the ascitic fluid total protein in hepatic and non-hepatic causes of ascites. The research period covered the years of June, 2021 to May 2022.
Results: The diagnostic accuracy of SAAG against AFTP was evaluated for determining the etiological causes of ascites in patients, and the results showed that SAAG -Serum Ascitic Fluid Albumin Gradient was superior to AFTP.
Conclusion: In determining the cause of ascites, the SAAG is preferred over the previously used AFTP classification system. The ascites is divided into two categories, high SAAG and low SAAG, according on the SAAG value


Dr. Nikhila Phadnis, Dr. Govind Shiddapur, Dr. Nidhi Rana, Dr. Prateek Harsh .

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 8, Pages 2539-2543

Liver abscesses can be tricky to diagnose, with varying etiologies. As seen in this case of a 40-year-old male, who presented with pain abdomen and vomiting. A contrast scan revealed a giant hepatic abscess, with an impending perforation. A percutaneous drain was immediately inserted. Over the course of four months, the abscess was drained completely.

A Hospital Based Prospective Study to Compare the Serum Ascitic Fluid Albumin Gradient (SAAG) with Ascitic Fluid Total Protein (AFTP) in Hepatic and Non-Hepatic Causes of Ascites at Tertiary Care Center

Mukesh Kumar Khinchi, Shiv Kumar Goyal, Mukesh Sonkaria, Aashish Kumar Bagarhia

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 7, Pages 375-381

Background: The traditional way of classification of ascites by AFTP offers little insight to the pathophysiology of ascites formation and it has further drawbacks. In order to overcome it the classification of ascites based on SAAG has emerged. Even SAAG also has some draw backs like non correlation with ascites due to nonalcoholic cirrhosis and difficulty in identifying the ascites due to mixed etiology. So, the study is conducted to compare the serum ascetic fluid albumin gradient (SAAG) with ascetic fluid total protein (AFTP) in hepatic and non-hepatic causes of ascites at tertiary care center.
Materials& Methods: A hospital based prospective study done on 80 patientswho were admitted in the medical ward under Department of General Medicine, General surgery and radiation oncology in SMS Medical College, Jaipur, Rajasthan. They are classified on the basis of SAAG into High SAAG and low SAAG and on the basis of AFTP into Transudate and Exudate. After the etiology of ascites evaluated by various diagnostic procedures the sensitivity, specificity and diagnostic accuracy of SAAG and AFTP in identifying the pathophysiology of ascites calculated separately. The diagnostic accuracies of SAAG and AFTP compared statistically.
Results: Our study showed that the mean age was 50.23 years. Male to female ratio was 2.33:1. The cirrhosis occupies the maximum with 60%, liver metastasis, Antenatal with Hypertensionoccupiestheleastwith1.25%each. The diagnostic accuracy of SAAG and AFTP for individual aetiologies of ascites were found and compared. SAAG was found to be superior to AFTP with a P value of <0.01 which was statistically significant.
Conclusion: We concluded that the diagnostic accuracy of SAAG and AFTP was compared and SAAG was found to be superior to AFTP and it was proved statistically significant.

A study of acute inflammatory proteins and its relevance in Covid-19

Dr. Reddy Spoorthi Channa, Dr. Aparna, Dr. Reddy Channa

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 2, Pages 1471-1474

Background: The mortality rate covid-19 is still not understood completely but was reported around five percent worldwide. This study puts in an effort to find one such difference if any between the survivors when compared to the non-survivors. This study makes an effort to find the acute inflammatory proteins in the survivors in comparison with the non-survivors.
Aims and Objectives: To study the acute inflammatory proteins levels and their significance in Covid-19.
Materials and Methods: This is a retrospective study done in the Department of Medicine, Dr. Chandramma Dayanand Sagar Institute of Medical Education and Research, Bangalore.
Results: There is a significant difference in the levels of acute inflammatory protein levels in survivors when compared to that of non-survivors.
Conclusion: This study successfully portrays the importance of acute inflammatory protein levels in understanding the progression of the disease.