European Journal of Molecular & Clinical Medicine

Introduction: Diabetic foot has become the common indication for hospital admissions
among diabetics. The diabetic foot commonly begins as an ulcer. So rapid and extensive
is the underlying damage that approximately 20% of these patients end up with
amputation. The present study has been performed to compare the efficacy of collagen
dressing with that of conventional dressing materials like silver sulfadiazine,
nadifloxacin, povidone iodine.
Materials and Methods: Fifty patients (40 males and 10 females) were procured to be
included to experimental group who were treated using collagen dressing and they form
the study group. Control treatment was performed on 25 patients (21 males and 4
females) at the same period. All the quantitative values were noted as mean± standard
deviations.
Results: 1. The final ulcer sizes (by the 3-week measurement) ranged between 0.2 and
4.2 cm2 (mean, 1.11 ± 1.19 cm2) in the experimental group, and ranged between 0.1 and
12.8 cm2 (mean, 2.52 ± 2.61 cm2) in the control group. It was found that all of 25
patients of the experimental group were reported with shrinkage of wound area and
depth over 30% at the third week regardless of wound location, duration, and grade. In
contrast, the improvement of only 5 ulcers in area over 30% at the third week was
observed, and 6 in depth.
Conclusion: Collagen dressing also might also provide supplementary advantages of
patients’ comfort and compliance as well as maintenance of ideal healing environment.
In order to confirm the usefulness and wound healing potential of collagen dressing in
the management of diabetic foot ulcers, future research with longer follow-up periods
should be conducted.

Due to the increased resistance rate of Escherichia coli and Pseudomonas aeruginosa among
gram-negative bacteria, the risk factors of drug-resistant negative bacilli in patients should be
evaluated in the development of initial anti-infective treatment regimen in clinical practice. In
this study, multidrug-resistant bacteria accounted from the strains obtained by wound
cultures, which may be related to the patients with serious illness admitted to our hospital as a
tertiary care hospital and the more complex history of antibacterial drug use. This study puts
in a sincere effort to find the risk of diabetic foot ulcer with multidrug-resistant organism
infection.