Online ISSN: 2515-8260

Keywords : normal saline

Intravenous Lornoxicam for Attenuation of the Cardiovascular Response to Laryngoscopy and Endotracheal Intubation

Febin Sathar, Sreedevi CR, Roshin Reeba Joseph, Divya D .

European Journal of Molecular & Clinical Medicine, 2023, Volume 10, Issue 2, Pages 859-865

Purpose: The purpose of this study was to determine the hemodynamic effect of intravenous lornoxicam during laryngoscopy and endotracheal intubation and to determine whether intravenous lornoxicam is effective in reducing the hemodynamic stress response to laryngoscopy and endotracheal intubation.
Methods: It was a double blind randomized control trial to investigate the effect of lornoxicam on the change in blood pressure, heart rate observed during laryngoscopy and tracheal intubation in 50 ASA class I and II patients. 50 patients with similar characteristics were divided into groups of 25 each. One group received lornoxicam, while the other received a placebo.
Results: Blood pressure and heart rate was recorded at various intervals during laryngoscopy and endotracheal intubation.  It was observed that there was a significant attenuation in heart rate and blood pressure response to laryngoscopy and intubation for the lornoxicam group.
Conclusion: The use of IV lornoxicam during laryngoscopy and intubation can save lives since it significantly lowers the hemodynamic reactions to intubation when administered 30 minutes prior to the surgery.

A Effect of Nebulized Magnesium Sulphate on the Incidence of Postoperative Sore throat

Dr. Neha, Dr. Nidhi kumari, Dr.Taqui Fakhri, Dr. Divya Jyoti

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 7, Pages 2577-2583

Background: Postoperative sore throat (POST) is a well-recognized complication that remains unresolved in patients undergoing endotracheal intubation for general anesthesia. The wide variation in these figures is presumably due to different skills and techniques among anesthetists and to differences between patients in the definition of sore throat. Objective: The main aim is to study the attenuating effect of Magnesium sulphate nebulization on the incidence of postoperative sore throat. Materials and Methods: This is a prospective, comparative and observational study conducted in the Department of Anaesthesia and Intensive care unit, NC Medical College and Hospital over 1 year. 90 cases divided into two equal groups. Patients included in the study were of either gender belonging to American Society of Anesthesiologists (ASA) status 1 or 2 undergoing elective surgery of approximately 2 h or more duration requiring tracheal intubation. Patients in Group N were nebulized with 3 ml of normal saline and the patients in Group M were nebulized with 3 ml of 225 mg isotonic nebulized magnesium sulfate for 15 min. The incidence of POST at rest and on swallowing at 0, 2, 4, 12, and 24 h in the postoperative period was evaluated. Results: There was no significant difference in POST at rest, at 0th, 2nd, and 4th h between normal saline and MgSO4. The significant difference was seen at 24th h, where MgSO4 lessened POST. There is no significant difference in POST on swallowing at 0th and 2nd h between normal saline and MgSO4. The significant difference was seen at 4th h, where MgSO4 lessened POST. Conclusion: POST is common in patients undergoing GA with a tracheal tube for routine surgical cases for up to 24 hr. We conclude that the use of magnesium sulphate in the form of nebulization as a pre-medication agent significantly reduces the incidence of POST compared to normal saline and it was found to be safe, simple, and effective in preventing the occurrence of postoperative sore throat.


Dr. Sreenivas Azmeera, Dr. Chandrashekhar Botla, Dr. Voviliveni Srikala, Dr. B Srinivas, Dr. Bheemanadhuni Anusha

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 4, Pages 3336-3341

Aim: The purpose of the present research was evaluating the effects of magnesium sulphate on arterial blood pressure in cases of elective laparoscopic surgeries.
Methodology: 200 patients who underwent laparoscopic abdominal surgery were randomly divided in to two groups, group A and group B. Group A received magnesium sulphate 50 mg/kg diluted in normal saline to total volume of 20 ml at 240 ml/hour over 5 minutes. The control group (group B) received same amount of normal saline (20 ml).
Results: The baseline characteristics of the magnesium sulphate and Control groups were comparable and there was no significant difference between the groups. Systolic and Diastolic BP were higher in Control group than magnesium group. There was no significant difference in sedation levels in both groups.
Conclusion: In our study, we conclude that IV magnesium sulphate, when given before pneumoperitoneum attenuates arterial pressure increase during elective laparoscopic abdominal surgeries. This attenuation is apparently related to reductions in the release of catecholamine, vasopressin or both by magnesium sulphate.