European Journal of Molecular & Clinical Medicine

Preservative free Chloroprocaine (CP) seems like a promising alternative, being a short acting agent of increasing popularity in recent years. While Chloroprocaine was withdrawn from the market in the 1980s because of concerns about neurotoxicity a new formulation without preservatives that has no longer been associated with neurotoxicity was introduced in clinical routine. After taking informed and written consent, 40 patients of either sex, aged between 18-60years, belonging to American Society of Anaesthesiologists Physical status I to III, undergoing elective perianal surgeries under spinal anaesthesia enrolled in this observational study. Our study showed mean time of onset of motor block was 8.38±1.25 minutes, mean time to achieve maximum motor block 9.45±0.71 minutes and mean time for motor regression to bromage scale 0 was 65.68±15.19 minutes. The time to void was 98.32±15.80 min and time to ambulation was 89±15.30 min the time of first postoperative analgesic requirements was 96.32±12.83 min.

Spinal anaesthesia is a safe and reliable technique for surgery of the lower abdo­men and lower limbs. Nevertheless, some of its characteristics may limit its use for ambulatory surgery, including delayed ambulation, risk of urinary retention, and pain after block regression. The choice of the correct local anaesthetic for spinal anaesthesia is therefore crucial in the ambulatory setting: the ideal anaesthetic should allow rapid onset and offset of its own effect for fast patient discharge with minimal side effects.
Aims: To compare the duration of sensory and motor blocks with use of chloroprocaine, and levobupivacaine as local anaesthetics in spinal anaesthesia.
Materials and method: The present study was a Prospective randomized open label double blind study. This Study was conducted From 18 months, from February 2018 to July 2019 at Department of Anaesthesia, Bankura Sammilani Medical College and Hospital. Total 72 patients were included in this study.
Result: We found that, In group-C, the mean duration of surgery (mean ±s.d.) of the patients was 43.7500 ± 5.6537 mins. In group-L, the mean duration of surgery (mean ±s.d.) of the patients was 44.5833 ± 4.3712 mins. There was no statistically significant difference in ASA gradings in between two groups (p=0.4865). There was no statistically significant difference in mean time to reach peak block height in between two groups (p=0.6142). In group-C, the mean two segment regression time (mean ±s.d.) of the patients was 57.0833 ± 8.5670. In group-L, the mean two segment regression time (mean ±s.d.) of the patients was 80.5833 ± 7.4234. There was statistically significant difference in mean two segment regression time in between two groups (p<0.001). There was statistically significant difference in mean time for regression to L1 in between two groups (p<0.001). There was   no statistically significant difference in PEAK BLOCK HEIGHT in between two groups. (p=0.4004).
Conclusion: we conclude that in patients undergoing unilateral knee arthroscopy, the use of chloroprocaine was associated with decreased time of duration of sensory and motor block and early recovery, early ambulation and early void. There were no statistically significant difference is noted in haemodynamic changes in between two groups. No adverse effects regarding allergic reactions, hypotension, shivering, bradycardia  and nausea and vomiting were  found during intraoperative and postoperative period.

Introduction: Spinal anaesthesia is a safe, reliable, inexpensive anaesthetic technique for regional anaesthesia. It also allows early ambulation and early rates of hospital discharges.
Material and methods: Present study was carried at tertiary care Hospital. After receiving ethical approval from the college ethical committee and CTRI registration, 64 patients aged 19 to 65 years old with ASA grade I and II physical status who were undergoing elective infra-umbilical surgeries were included in the study. Patients were randomly allocated in two groups of 32 patients each. Group C: Received 1% Isobaric Chloroprocaine 3 ml (30mg) + clonidine (30 mcg). Group F: Received 1% chloroprocaine 3ml (30 mg) + fentanyl (25 mcg). Total volume = 3.5ml. Sensory block was examined using pin prick method. Quality of motor block was examined and graded using Modified Bromage Scoring. Hemodynamic was monitored and side effects were noted.
Result: Total 64 patients were divided into two groups of 32 each. There were 17 males and 15 females in Group F. While in Group C, male and female participants were 16 each. In group F, mean onset time of sensory blockade was (3.69 ± 0.41min) and mean onset of motor blockade was (5.14 ± 0.65min). In group C, mean onset time of sensory blockade was (3.86 ± 0.28min) and mean onset of motor blockade was (5.31 ± 0.63min). In group F, mean duration of sensory blockade was (74.19 ± 3.14min) and mean duration of motor blockade was (60.24 ± 2.97min). In group C, mean duration of sensory blockade was (110.34 ± 8.45min) and mean duration of motor blockade was (94.88 ± 4.39min). In group F, 1 patient had hypotension and bradycardia while in group C,4 patients had hypotension and 3 had bradycardia. Transient neurological symptoms, respiratory depression and pruritis were not seen in any of the groups.
Conclusion: From our study we conclude that, clonidine as an adjuvant to intrathecal chloroprocaine can be used for infra-umbilical ambulatory surgeries with good sub-arachnoid block quality and lesser side effects.

Caesarean sections are routinely done under spinal anaesthesia using 0.5% hyperbaric bupivacaine that has a long duration of action. As most of the caesarean sections are of short duration, we decided to compare 1% 2-chloroprocaine with routinely used bupivacaine as chloroprocaine has rapid onset of action, producing an excellent sensory and motor blockade. After ethical committee clearance and informed written consent, 70 uncomplicated singleton parturients of ASA I and II posted for elective caesarean section were randomised into chloroprocaine (CP) and bupivacaine (B) group of 35 each.
Onset of sensory block in group CP was 1.71±0.62min and in group B was 2.31±0.63min. Onset of motor block in group CP was 2.54±0.88min and in group B was 2.66±0.76min. Mean time for maximum sensory block in group CP was 12.77±3.52min and in group B was 22.34±6.46min and time for maximum motor block in group CP was 9.14±2.23min and in group B was 10.86±2.18min. Two segment regression time in group CP was 39.34±4.46min and in group B was 63.14±4.7min. Mean duration of sensory block in group CP was 2.08±0.25hr and in group B was 3.60±0.27hr and duration of motor block in group CP was 1.07±0.14hr and in group B was 3.42±0.41hr. VAS scores in first 6hrs were lesser in group CP than group B. Onset, maximum time, duration of sensory and motor block were lower in group CP than group B. hemodynamic parameters were comparable between the groups with no side effects.