Online ISSN: 2515-8260

Keywords : Haemophagocytosis


Evaluation of Clinical Features and Risk Factors of Thrombocytopenia Syndrome in Association with Severe Fever: An Institutional Based Study

Ashok Parmar

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 5742-5747

Introduction: Severe fever with thrombocytopenia syndrome is found to be gradually
increasing every year and it is reported to be caused by group of viruses which belong
to the group of Phlebovirus genus in Bunyaviridae family. The prime goal of this study
is to determine the risk factors in patients with SFTS and to reduce the severity of SFTS
through early intervention.
Materials and Methods: A total of 65 laboratory-confirmed cases and the complete
medical records were thoroughly checked and clinical and laboratory features were
compared. All significance tests were two-tailed and P values < 0.05 were considered
statistically significant.
Results: The major clinical manifestations of SFTS were fever (100%), fatigue (76.5%),
diarrhoea (49.02%), myalgia (47.1%), nausea (43.14%) and vomiting (31.4%). The
symptoms of central nervous system characterized by conscious disturbance were found
in 37 cases (56.9%). Bone marrow examinations were performed in 29 patients and
heteromorphic lymphocyte and haemophagocytosis could be observed in SFTS patients.
Conclusion: The identified clinical and laboratory parameters might predict severe
outcome and various novel treatment strategies such as effective vaccine or antiinflammatory
therapy are in much of necessity in people living in a SFTS prone areas