Online ISSN: 2515-8260

Keywords : Schiff base


Anti oxidant, Anti Inflammation and Anti Diabetic Activity of Novel Schiff Base Derived from 2-Hydroxy benzoic acid (3-Hydroxy benzylidine)-Hydrazide and 2-Hydroxy benzoic acid (3-Hydroxy -4-methoxy benzylidine)-Hydrazide

V. Anusuya; G. Sujatha; G. B. Broheshnu; G. L. Balaji

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 4, Pages 2523-2532

A series of new 2-Hydroxy benzoic acid (3-Hydroxy benzylidine)-Hydrazide and 2-Hydroxy benzoic acid (3-Hydroxy -4-methoxy benzylidine)-Hydrazide based Schiff base derivatives, have been synthesized. Synthezied Schiff base ligands were screened for anti- oxidant, anti inflammation, and anti diabetic activity. The compounds were screened for their Antioxidant activity was evaluated by DPPH radical scavenging method and compared with standard ascorbic acid. Anti inflammation activity were examined by albumin denatuation and compared with standard aspine. Antidiabetic activity against α-amylase enzyme and compared with standard drug acarbose.

Synthesis of New Reagents as a ligands and Study of (Investigation, Chromatographic Behavior, Solubility)

Dr. Fatimah A. Wannas; Nemah Sahib Mohammed Husien; Dr. Afaq Jaber Kadhium; Dr. Nagham Mahmood Aljamali

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 5266-5279

Formazane ligands are described by many chemical and physical properties that have increased their applications in several fields and therefore have been classified as reagents or ligands with donor or multi-sites. Multiple methods have been used to prepare aldamine and formazane reagents, including imination reactions, condensation, substitution, duplication, including the formation of the carbanion and the reaction of nitrogen in coupling reaction. It is followed by investigation of prepared ligands by various sources that improved all results in this paper via various spectral measurements in inorganic chemistry area like (Uv-Vis, FT.IR, H.NMR) - spectra, besides to other measurements in analytical area like: (solubility, chromatographic behavior, TLC –plate), besides to bio- assay as antibacterial compounds for determination of efficiency of inhibition and other chemical characterizations (melting points, Rf, …).