European Journal of Molecular & Clinical Medicine

A series of new 2-Hydroxy benzoic acid (3-Hydroxy benzylidine)-Hydrazide and 2-Hydroxy benzoic acid (3-Hydroxy -4-methoxy benzylidine)-Hydrazide based Schiff base derivatives, have been synthesized. Synthezied Schiff base ligands were screened for anti- oxidant, anti inflammation, and anti diabetic activity. The compounds were screened for their Antioxidant activity was evaluated by DPPH radical scavenging method and compared with standard ascorbic acid. Anti inflammation activity were examined by albumin denatuation and compared with standard aspine. Antidiabetic activity against α-amylase enzyme and compared with standard drug acarbose.

Formazane ligands are described by many chemical and physical properties that have increased their applications in several fields and therefore have been classified as reagents or ligands with donor or multi-sites. Multiple methods have been used to prepare aldamine and formazane reagents, including imination reactions, condensation, substitution, duplication, including the formation of the carbanion and the reaction of nitrogen in coupling reaction. It is followed by investigation of prepared ligands by various sources that improved all results in this paper via various spectral measurements in inorganic chemistry area like (Uv-Vis, FT.IR, H.NMR) - spectra, besides to other measurements in analytical area like: (solubility, chromatographic behavior, TLC –plate), besides to bio- assay as antibacterial compounds for determination of efficiency of inhibition and other chemical characterizations (melting points, Rf, …).