Online ISSN: 2515-8260

Keywords : gold nanoparticles

Development, Analysis and Evaluation of Arsenic (III) Sensor

Hema. R; Sundararajan M

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 4, Pages 2533-2551

Pollution or contamination plays a major part in dreadful health hazards. Water, the most essential entity for life is being consumed without the knowledge of contaminants. Arsenic (As III) above 10μg/L is regarded to be poisonous to life and causes lung or skin cancer and cardiovascular geotaxis, mutagenic &carcinogenic effects. Contamination of As may not only occurs in under or drinking water but also in sea water which may be a health threat to aquatic lives. Arsenic decontamination need to be strictly adopted upon any form of water purification. A special technique for the determination by express sensing of arsenic ionic level in water was examined on a Smooth or Glassy carbon electrode (GCE) with nano Gold transformation in 0.5 M H2SO4. The nano Gold was setup using a cycling potential continuously ranging from 0.619 to-0.481 V (vs. HAuCl4.3H2O) Chloro Auric Acid in 0.5 M H2SO4 solution. The Gold nano particles are electro- deposited on GCE. The electrode was examined by Differential Pulse Voltammetry (DPV), Anodic Stripping Voltammetry (ASV), Linear Sweep Voltammetry (LSV) and cyclic Voltammetry (CV). After optimization, a LOD (Level Of Detection) of 0.9 parts per billion (ppb) was achieved with a 60s transformation at -0.94 V in 0.5 M H2SO4whereas the WHO’s (World Health Organization) maximum allowable arsenic level is 10 ppb, in drinking water. Mercury Mercurious Sulphate (MMS) was used as standard reference electrode. The developed sensor was evaluated for copper ion interference and was found to have no interfering effect due to ionic copper which is the most potential obstructing ionic species in ionic arsenic determination.

Antiangiogenic Effects Of Ktp Laser Activated Gold Nanoparticles In Prevention Of Neovascularization

Kareem Esam; Lilian Naoum; Maha Fadel; Mahmoud Saber

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 3513-3522

This study examines the antiangiogenic effect of activated naked gold nanoparticles (AuNPS) in dorsal skinfold window chamber rat model after laser coagulation of dorsal blood vessels, to investigate whether the antiangiogenic effect of AuNPs can inhibit reperfusion and neovascularization of photocoagulated blood vessels in an animal model.This study includes 2 groups, each group contains 10 rats, laser group (control group), and AuNPs group. After laser photocoagulation of dorsal blood vessels through the dorsal window chamber fixed on the dorsum of albino rats, the structure of blood vessels and flow dynamics were documented with color digital photography to evaluate photocoagulation and reperfusion. The laser sessions and injection of AuNPs to the epidermal side of the window were twice weekly for 2 weeks. In the laser group (control group), 18 out of 20 photocoagulated blood vessels reperfused within 4-12 days with reperfusion rate 90%. In AuGNPs group 9 out of 22 photocoagulated blood vessels reperfused within 4-12 days with reperfusion rate 40%. Laser activated naked gold nanoparticles have significant antiangiogenic effect, with minimal side effects detected with local use.