Online ISSN: 2515-8260

Keywords : Atracurium

Comparison of Atracurium versus Cisatracurium Regarding Onset Time, Intubating Conditions and Haemodynamic Parameters and Duration of Action

Nikita Baser, Vijay kumar, Shilpa Sharda, Neetu Maurya

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 5, Pages 132-137

Background:Endotracheal intubation is an integral part of the administration of general anesthesia during the surgery. Neuromuscular blocking agents facilitate general anaesthesia. cisatracurium having lack of histamine release, which provides better cardiovascular stability in comparison to atracurium. To compare of atracurium and cisatracurium onset time, intubation conditions, hemodynamics and duration of block.
Materials and Methods: The present study was a prospective randomize, conducted in the Department of Anaesthesia, Pacific medical college and hospital Udaipur, Rajasthan. Total 70 ASA Grade I/II patients in the age group of 18-60 years posted for elective surgery required general anesthesia were selected in this study.  Patients were divided into two groups of 35 each. Group A patients received atacurium 0.5 mg/kg as loading dose while Group B cisatracurium 0.2mg/kg, The onset time,intubating conditions hemodynamic parameters and duration of action were noted.
Results: Cisatracurium have rapid onset (p<0.001) and long duration of action (p<0.001) and stable mean arterial pressure (p<0.001) and better intubating conditions (p=0.04.).
Conclusion: Cisatracurium provides rapid onset, excellent intubating conditions, long duration of action and good haemodynamic stability in comparision to atracurium.

Comparative study of Equipotent Dose of Cisatracurium and Atracurium in Patients Undergoing Abdominal Laparoscopic Surgeries

Dr. Harish Uppala, Dr. Mamidi Ajay Kumar, Dr. Santhosh Chinta, Dr Jajjari Prashanth

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 6001-6008

Introduction: Cisatracurium is one of the ten stereoisomers of Atracurium and is devoid of
histamine induced cardiovascular effects. The neuromuscular blocking potency of
Cisatracurium is approximately three-fold that of Atracurium. Neuromuscular transmission
was assessed by recording the muscle twitch response to train-of-four nerve stimulation.
Material and Method: This is a prospective study was conducted in the Department of
Anesthesiology, Tertiary care Teaching Hospital over a period of 1 year among 140 patients
aged between 20 and 45 years. Study was performed in 140 patients aged 20-45 years
weighted 40-70 kilograms with ASA physical grading 1 and 2 of either sex scheduled for
elective laparoscopic surgery. Monitoring – ECG, non-invasive blood pressure, pulse
oximetry, temperature and capnography (EtCO2). In operation theatre intravenous cannula of
proper size was inserted into the largest vein on the forearm and an infusion of lactated
ringer’s solution was started at a rate of 5 ml/kg/hr. Induction – inj. Propofol 2 mg per kg.
Patients were divided into 2 groups: Group 1 - 70 patients were given atracurium 0.5 mg per
kg for induction. Group 2 - 70 patients were given cisatracurium 0.1 mg per kg for induction.

Effect of atracurium and cisatracurium as nondepolarising neuromuscular blocking agents: A comparative study

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 2, Pages 1698-1703

Introduction: General anesthesia, for a surgical procedure is normally done with the help of endotracheal intubation. The non-depolarizing muscle relaxant, or the non depolarising muscular blocking (NMBA) agents are known to inhibit the action of acetylcholine, while differing in the onset and the duration of action, potency, metabolic route and side effects. The main aim of this study was to compare the neuromuscular blockade of atracurium and Cisatracurium and the recovery characteristics.