Online ISSN: 2515-8260

Keywords : Panss Negative Symptom

Study of Soft Neurological Signs in Schizophrenia Patients

Pruthvi Reddy Muddasani, Charan Teja Koganti, Janagam Sheetal Reddy

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 6085-6093

Background:Soft neurological symptoms have been observed in patients with
schizophrenia. Several studies have shown neurological abnormalities in schizophrenia
patients, but their presence has been complicated by a number of potentially
confounding variables such as the duration of the illness, drug doses, and the use of
diverse assessment methodologies. Soft neurological symptoms appear to be a
characteristic component of schizophrenia as well as a probable biological indication of
prognosis. As a result, early detection and action may result in a better prognosis. The
assessment of soft neurological symptoms is a straightforward, simple, and low-cost
method of determining the severity of brain dysfunction in schizophrenia. The
relationship between the presence of schizophrenia and soft neurological symptoms in a
patient has not been widely examined in the context of the Indian population. As a
result, the purpose of this study is to assess the presence of mild neurological symptoms
in individuals with schizophrenia.
Materials and Methods: 80 subjects, 40 patients with schizophrenia and 40 healthy
matched controls were evaluated. Tools used were PANSS for evaluation of
symptomatology in schizophrenia patients, NES for evaluation of neurological soft
signs, MMSE for evaluation of cognitive functions and SESS for evaluation of socioeconomic
Results: When compared to controls, patients with schizophrenia had significantly
higher NES scores. Age, gender, educational position, and disease duration show no link
with the existence of soft neurological symptoms in individuals with schizophrenia,
according to socio-demographic and clinical characteristics. There are statistically
significantpositive associations between the PANSS negative symptom subscale, the
Total PANSS score, and the NES scores in patients with schizophrenia. In
schizophrenia patients, there is a substantial negative connection between the Total
NES score and the Total MMSE score.
Conclusion: Wound infection following previous surgery was the most important risk
factor associated with incisional hernia. The other risk factors were obesity and COPD.
Polypropylene mesh repair is superior to anatomical repair as it has less recurrence.