European Journal of Molecular & Clinical Medicine

Introduction: The most important attributes of female body which makes it possible for procreation, is menstrual cycle. In proliferative phase estrogens gradually increase, causing Follicle stimulating harmone and Luteinizing harmone to peak, whereas progesterone remains low throughout. The secretory phase is dominated by the actions of estrogen and progesterone. Reproductive hormones may modulate cardiovascular function through a number of mechanisms.
 Aim of study – To assess the variation in cardiovascular function using recording of pulse and blood pressure indices in different phases of menstrual cycle in females having normal menstrual cycle.
Material And Method – – 50 apparently healthy female aged between 20-25 years were selected for the study and pulse and blood pressure was recorded using automatic blood pressure monitor during the different phase of menstrual cycle as follows: a)Menstrual phase(MP) (2nd day) b)follicular phase(PP) (11th day) c) secretory phase(SP) (22nd day).
Results – After statistical analysis (paired t-test) the finding of study was decrease in systolic BP and mean BP during follicular phase as compared to menstrual phase. But there was significant decrease in diastolic BP and mean BP during secretory phase as compared to menstrual phase. Though there was no significant difference in pulse rate but significant change in pulse pressure between follicular and secretory phase has been shown in present study.
Conclusion – The effect of endogenous change in hormonal which are the physiological changes during different phases of menstrual cycle supports the result of study

Purpose: During menstrual cycle the fluctuating level of endogenous sex hormones have
an impact on cardiac autonomic function and may also affect blood volume along with
electrocardiographic pattern. The main purpose of the study was to compare and
evaluate variation in electrocardiogram, heart rate variability and hypertension during
different phases of menstrual cycle to determine the effect of ovarian hormones on
cardiovascular function.
Methods: This was a cross sectional prospective study conducted in 145 healthy female
student who had regular menstrual cycle of 30 ± 3 days and aged between 18 to 24 years
after taking informed consent and institutional ethical clearance. In different phases of
menstrual cycle [Menstrual Phase (day 1-5), Follicular Phase (day 5–14) and Luteal
phase(day 15-28)] blood pressure, lead II electrocardiogram recordings were captured
and by using PHYSIOPAC after connecting the limb leads of ECG in supine resting
position with eyes closed HRV was assessed for 15min.
Results: On electro gram parameters a significant QT interval and RR interval were
observed. Longer QT interval during follicular Phase and shorter QT interval during
Luteal phase were recoded where as shorter RR interval observed during Menstrual
Phase which were longer during luteal phase. During the three phases no significant
variation in both systolic and diastolic blood pressure were noticed. An increase resting
heart rate were noted during menstrual phase which was lower during luteal phase. A
non-significant increase in LF nudomain and LF/HF ratio were noted during the luteal
phase as compared to other phases. Compared to luteal phase, during the follicular
Phase, in LF nudomain and LF/HF ratio a non-significant increase were observed.
Conclusion: In healthy young women with regular menstrual cycle sympathovagal
balance were greatly influenced by endogenous sex hormones. Cardiacautonomic
dysfunction and be resulted due to any type of hormonal imbalance which effect
sympathovagal balance. The study also concluded even within range of fluctuations,
ventricular action potentials were were greatly influenced by estrogen as QT and Q Tc
intervals shows changed in healthy young adults.